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Material for Screening For Compound Acting on ION Channel and Use Thereof

  • US 20190331664A1
  • Filed: 11/01/2017
  • Published: 10/31/2019
  • Est. Priority Date: 11/01/2016
  • Status: Active Grant
First Claim
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1. A screening material for agonists or inhibitors for a target ion channel, wherein the screening material contains cells comprising:

  • a voltage-dependent Na ion channel that prolongs the duration of an action potential associated with depolarization,a K ion channel that deepens a resting membrane potential in the negative direction, anda target ion channel that is an ion channel that contributes to deepening the resting membrane potential in the negative direction and/or that shortens the duration of the action potential associated with depolarization,wherein the Na ion channel, the K ion channel, and the target ion channel constitute a cell death induction system with which cell death is induced by the induction of depolarization in the presence of an inhibitor for the K ion channel.

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