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SYSTEMS AND METHODS FOR GENERATING, VISUALIZING AND CLASSIFYING MOLECULAR FUNCTIONAL PROFILES

  • US 20190332744A9
  • Filed: 06/12/2018
  • Published: 10/31/2019
  • Est. Priority Date: 06/13/2017
  • Status: Active Grant
First Claim
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1. A system, comprising:

  • at least one computer hardware processor; and

    at least one non-transitory computer-readable storage medium storing processor-executable instructions that, when executed by the at least one computer hardware processor, cause the at least one computer hardware processor to perform;

    obtaining RNA expression data and/or whole exome sequencing (WES) data for a biological sample from a subject;

    determining a molecular-functional (MF) profile for the subject at least in part by determining, using the RNA expression data, a gene group expression level for each gene group in a set of gene groups comprising;

    first gene groups associated with cancer malignancy consisting of the tumor properties group; and

    second gene groups associated with cancer microenvironment consisting of the tumor-promoting immune microenvironment group, the anti-tumor immune microenvironment group, the angiogenesis group, and the fibroblasts group,determining a first set of visual characteristics for a first plurality of graphical user interface (GUI) elements using the gene group expression levels determined for the first gene groups;

    determining a second set of visual characteristics for a second plurality of GUI elements using the gene group expression levels determined for the second gene groups;

    generating a personalized GUI personalized to the subject, the generating comprising;

    generating a first GUI portion associated with cancer malignancy and containing the first plurality of GUI elements having the determined first set of visual characteristics; and

    generating a second GUI portion associated with cancer microenvironment and containing the second plurality of GUI elements having the determined second set of visual characteristics; and

    presenting the generated personalized GUI to a user.

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