TISSUE COLLECTION AND DELIVERY DEVICE AND METHODS OF USE THEREOF

• US 20190336142A1
• Filed: 07/15/2019
• Published: 11/07/2019
• Est. Priority Date: 01/26/2018
• Status: Active Grant

• Current Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Original Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Inventors: Torrie, Paul Alexander, Krause, Kenneth W.
• Granted Patent: US 10,639,046 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 17/1615 Drill bits, i.e. rotating tools extending from a handpiece to contact the worked material
• CPC Class Codes: A61B 17/162 Chucks or tool parts which are to be held in a chuck
• CPC Class Codes: A61B 17/1622 Drill handpieces A61B17/1626, A61B17/1628 take precedence
• CPC Class Codes: A61B 17/1631 Special drive shafts, e.g. flexible shafts A61B17/1642, A61B17/164 take precedence
• CPC Class Codes: A61B 17/1635 for grafts, harvesting or transplants
• CPC Class Codes: A61B 17/1646 with sealing means
• CPC Class Codes: A61B 2017/00398 using powered actuators, e.g. stepper motors, solenoids
• CPC Class Codes: A61B 2017/00464 for use with different instruments with hole for different instruments A61B2017/22072
• CPC Class Codes: A61B 2017/00969 used for transplantation
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61F 2/4601 for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
• CPC Class Codes: A61M 2202/09 Body tissue
• CPC Class Codes: A61M 5/3145 Filters incorporated in syringes
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: C12M 45/02 by mechanical forces; Stirring; Trituration; Comminuting crushing, pulverizing, disintegrating in general B02C

Abstract

A system and method for harvesting autologous tissue, mincing it into fragments that are visible and measurable when filtered, and delivering a portion of the tissue back into the patient without the need to directly touch the tissue. During the same surgical procedure, the tissue can be mixed with a biocompatible agent before introduction into the repair site.

Claims

1. A tissue collection assembly comprising:

a resection system comprising;

a handpiece having a proximal end, a distal end, and a passageway therethrough;

a cannulated shaft attached to the distal end of the handpiece in fluid communication with the passageway, a distal end of the shaft comprising a cutting end; and

a filter assembly removeably attached to the proximal end of the handpiece in fluid communication with the cannulated shaft, the filter assembly comprising;

a housing allowing direct visualization of an internal volume of the housing; and

a filter disposed within the internal volume of the housing for collecting tissue on a surface of the filter.

2. The assembly of claim 1, further comprising a compressor extendable through the internal volume of the housing for compressing the collected tissue;

wherein the handpiece further comprises rigid tubing and a barb in fluid communication with the filter assembly, and wherein the compressor comprises an inlet for removeable attachment to the barb.

3. The assembly of claim 1, wherein the housing comprises a removeable outlet for attachment to a vacuum source, and wherein the filter is coupled to the outlet such that the filter and the outlet are removeable from the housing simultaneously.

4. The assembly of claim 1, wherein the housing further comprises a shearing member slidably disposed around the filter for removing the collected tissue from the filter.

5. The assembly of claim 1, wherein the resection system further comprises a flexible shield adjacent the cutting end of the shaft.

6. The assembly of claim 1, wherein the handpiece is a motorized drive unit.

7. The assembly of claim 1, wherein the handpiece comprises at least one internal structure to prevent contamination of the collected tissue by the handpiece.

8. The assembly of claim 7, wherein the at least one internal structure is one of a flow diverter and a sleeve integrated with the passageway of the handpiece.

9. The assembly of claim 1, further comprising one or more deformable wires for mixing the collected tissue with a biocompatible agent.

10. The assembly of claim 1, wherein the filter is a hollow, tubular filter, and the surface of the filter comprises holes in communication with an interior of the filter.

20. The assembly of claim 1, wherein the filter assembly is coupleable with a delivery device to deliver the collected tissue to a repair site.

11. A tissue collection assembly and delivery device combination comprising:

a tissue collection assembly comprising;

a resection system comprising;

a handpiece having a proximal end, a distal end, and a passageway therethrough;

a cannulated shaft attached to the handpiece in fluid communication with the passageway, a distal end of the shaft comprising a cutting end; and

a filter assembly removeably attached to the handpiece in fluid communication with the passageway, the filter assembly comprising;

a housing allowing direct visualization of an internal volume of the housing;

a filter removeably disposed within the internal volume of the housing for collecting tissue on a surface of the filter; and

a compressor extendable through the internal volume of the housing for compressing the collected tissue; and

a delivery device coupled to a coupling portion of the housing for delivering the collected tissue to a repair site.

12. The combination of claim 11, further comprising a plunger insertable through the compressor and a channel of the delivery device.

13. The combination of claim 12, further comprising an actuator for advancing the plunger within the channel of the delivery device and a mechanism for controlling the relative motion between the compressor and the plunger through a portion of the housing.

14. The combination of claim 13, wherein the mechanism is configured to prevent the advancement of the plunger through the housing until the compressor is stopped from advancing through the housing.

15. A method of collecting and delivering tissue to a repair site, the method comprising:

contacting a blade of a tissue collection assembly with tissue and cutting the tissue with a cutting end of the blade to create tissue fragments;

aspirating fluid and the tissue fragments through the blade to a filter assembly, the filter assembly comprising;

a housing allowing direct visualization of an internal volume of the housing, the housing in fluid communication with the blade;

a filter removeably disposed within the internal volume of the housing for collecting the tissue fragments on a surface of the filter; and

a compressor extendable through the internal volume of the housing for compressing the tissue fragments; and

a shearing member slidably disposed around the filter for removing the collected tissue from the filter;

separating the tissue fragments having a pre-selected size from the fluid using the filter;

detaching the filter assembly from the blade;

removing the filter from housing, thereby causing the shearing member to shear the tissue fragments from the surface of the filter;

coupling the filter assembly to a delivery device; and

inserting a plunger through the filter assembly and the delivery device to deliver the tissue fragments to a repair site.

16. The method of claim 15, further comprising extending the compressor within the housing to compress the tissue fragments such that a volume of the tissue fragments is measurable by direct visualization.

17. The method of claim 16, further comprising injecting a biocompatible agent into the housing and rotating one or more deformable wires attached to one of the compressor and the plunger to mix the tissue fragments and the agent.

18. The method of claim 16, further comprising actuating an actuator on the delivery device to advance the plunger within a channel of the delivery device.

19. A resection system comprising:

a handpiece having a proximal end, a distal end, and a passageway therethrough;

a cannulated shaft attached to the handpiece in fluid communication with the passageway, a distal end of the shaft comprising a cutting end; and

a filter removeably disposed within the shaft between the handpiece and the cutting end for collecting tissue on a surface of the filter.