NATURAL COMPOSITION FOR USE IN GYNAECOLOGY
First Claim
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1. An ozonized olive oil, comprising a peroxide value of 50-350 mEq 02/Kg comprising at least one liquid vegetable extract selected from among Allium spp., Aloe spp., Calendula officinalis, Cinnamomum spp., Curcuma spp., Lavender spp., Melaleuca spp., Plantago, Salvia officinalis, Salvia miltiorrhiza, Thymus spp., Zingiber spp. and mixtures thereof.
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Abstract
The present invention relates to a composition based on components of natural origin, in particular ozonized olive oil “ and liquid vegetable extracts, for the topical treatment of vaginosis and/or vulvovaginitis of bacterial and/or fungal origin.
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20 Claims
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1. An ozonized olive oil, comprising a peroxide value of 50-350 mEq 02/Kg comprising at least one liquid vegetable extract selected from among Allium spp., Aloe spp., Calendula officinalis, Cinnamomum spp., Curcuma spp., Lavender spp., Melaleuca spp., Plantago, Salvia officinalis, Salvia miltiorrhiza, Thymus spp., Zingiber spp. and mixtures thereof.
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2. The ozonized olive oil of claim 1, further comprising 0.5-10.0% by weight of at least one liquid vegetable extract selected from among Allium spp., Aloe spp., Calendula officinalis, Cinnamomum spp., Curcuma spp., Lavender spp., Melaleuca spp., Plantago, Salvia officinalis, Salvia miltiorrhiza, Thymus spp., Zingiber spp. and mixtures thereof.
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3. The ozonized olive oil of claim 1, wherein the at least one liquid vegetable extract comprises at least one essential oil selected from among Allium spp., Aloe spp., Calendula officinalis, Cinnamomum spp., Curcuma spp., Lavender spp., Melaleuca spp., Plantago, Salvia officinalis, Salvia miltiorrhiza, Thymus spp., Zingiber spp. and mixtures thereof.
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4. The ozonized olive oil of claim 1, further comprising 0.5-2.5% by weight of liquid vegetable extract of lavender.
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5. The ozonized olive oil of claim 1, further comprising 1.0-3.0% by weight or 1.2-2.5% by weight, of a mixture of liquid vegetable extracts comprising essential oils, of Lavender spp., Calendula officinalis and/or Melaleuca spp.
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6. The ozonized olive oil of claim 1, wherein said oil has a peroxide value of 100-350 mEq O2/Kg, 150-350 mEq O2/Kg, or 250-350 mEq O2/Kg.
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7. The ozonized olive oil of claim 1, wherein the ozonized olive oil is configurable for gynaecological use in the topical treatment of bacterial and/or fungal vaginosis and/or vulvovaginitis.
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8. The ozonized olive oil claim 7, wherein the ozonized olive oil id configurable for the topical treatment of vulvovaginitis caused by at least one pathogen selected from among fungi belonging to the genus Candida and Gardenerella vaginalis.
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9. The ozonized olive oil of claim 7, wherein said use comprises applying inside the vagina a pharmacologically effective amount, preferably 1-20 ml/die or 3-10 ml/die, of said ozonized olive oil.
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10. The ozonized olive oil claim 7, wherein said use comprises applying inside the vaginal cavity said ozonized olive oil for at least 3 days, for 3-6 days, every other day for at least 2 or for at least 3 administrations.
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11. The ozonized olive oil of claim 7, wherein said use comprises applying inside the vaginal cavity said ozonized olive oil for a period of at least 10 days;
- or for 10-20 days with 72-hour intervals between one application and the other.
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12. The ozonized olive oil of claim 1, wherein the ozonized olive oil is a component of a pharmaceutical composition comprising the ozonized olive oil and at least one pharmacologically acceptable excipient.
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13. The ozonized olive oil of claim 1, wherein the ozonized olive oil is a component of a medical device.
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14. The ozonized olive oil of claim 1, wherein the ozonized olive oil is a component of a pharmaceutical composition or a medical device, and wherein said composition or said device is in the form of an ointment, cream, gel, foam, emulsion, or solution.
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15. A pharmaceutical composition for gynaecological use, comprising:
- an ozonized olive oil comprising a peroxide value of 50 -350 mEq 02/Kg comprising at least one liquid vegetable extract selected from among Allium spp., Aloe spp., Calendula officinalis, Cinnamomum spp., Curcuma spp., Lavender spp., Melaleuca spp., Plantago, Salvia officinalis, Salvia miltiorrhiza, Thymus spp., Zingiber spp. and mixtures thereof, wherein the pharmaceutical composition is for use in the topical treatment of bacterial and/or fungal vaginosis and/or vulvovaginitis, wherein the vulvovaginitis is caused by at least one pathogen selected from among fungi belonging to the genus Candida and Gardenerella vaginalis.
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16. The ozonized olive oil of claim 1, wherein the at least one liquid vegetable extract comprises at least one essential oil comprising lavender essential oil.
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17. The ozonized olive oil of claim 1, further comprising 0.5-2.5% by weight of liquid vegetable extract of lavender essential oil.
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18. The ozonized olive oil of claim 7, wherein the ozonized olive oil is configurable for the topical treatment of vulvovaginitis caused by at least one pathogen selected from among Candida albicans, Candida glabrata and Gardenerella vaginalis.
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19. A method for topical treatment of bacterial and/or fungal vaginosis and/or vulvovaginitis, comprising:
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topically applying an ozonized olive oil to a subject, wherein the ozonized olive oil comprising a peroxide value of 50-350 mEq 02/Kg comprising at least one liquid vegetable extract selected from among Allium spp., Aloe spp., Calendula officinalis, Cinnamomum spp., Curcuma spp., Lavender spp., Melaleuca spp., Plantago, Salvia officinalis, Salvia miltiorrhiza, Thymus spp., Zingiber spp. and mixtures thereof; and treating bacterial and/or fungal vaginosis and/or vulvovaginitis, wherein the vulvovaginitis is caused by at least one pathogen selected from among fungi belonging to the genus Candida and Gardenerella vaginalis.
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20. The method of claim 19, further comprising the topical treatment of vulvovaginitis caused by at least one pathogen selected from among Candida albicans, Candida glabrata, and Gardenerella vaginalis.
Specification