SYNTHESIS OF 20-NOR-SALVINORIN A
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Abstract
The invention provides 20-nor-salvinorin A, an analog of the kappa-opioid agonist salvinorin A. The 20-nor-salvinorin A is an active kappa-opioid modulator and can be used for treatment of medical conditions wherein modulation of the kappa-opioid receptor is medically indicated, such as pain, pruritis, depression, or inflammation, or conditions implicating perception and consciousness. 20-nor-salvinorin A can be less additive when used in treatment compared to a mu-opioid receptor agonist, and 20-nor-salvinorin A is more stable in vivo than is parent compound salvinorin A. The invention further provides synthetic intermediates and procedures for preparation of 20-nor-salvinorin A.
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Citations
20 Claims
- 1. A compound of formula 20-nor-salvinorinA
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7-8. -8. (canceled)
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9. A compound of formula S11
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11-12. -12. (canceled)
- 13. A compound of formula S9
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15-19. -19. (canceled)
Specification