VMAT2 INHIBITOR COMPOUNDS AND COMPOSITIONS THEREOF
First Claim
1. A compound selected from compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof:
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Accused Products
Abstract
Provided is a compound selected from compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof: (I) wherein R1, R2, R3 and R4 are as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (VMAT2) and have utility for treating, for example, neurological and psychiatric diseases and disorders. Also disclosed are compositions containing such compounds in combination with a pharmaceutically acceptable carrier, as well as methods relating to their use in subjects in need thereof.
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Citations
83 Claims
- 1. A compound selected from compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof:
- 46. A compound selected from 3-(2,2-dimethylpropyl)-9,10-dimethoxy-2-methyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
- 48. A compound selected from 9-cyclopropoxy-10-methoxy-2-methyl-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H, 11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
- 50. A compound selected from 3-(2,2-dimethylpropyl)-10-methoxy-2-methyl-9-(2,2,2-trifluoroethoxy)-1H,2H2H, 3H,4H,6H,7H, 11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
- 52. A compound selected from 3-(2,2-dimethylpropyl)-9-ethoxy-10-methoxy-2-methyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
- 54. A compound selected from 3-(2,2-dimethylpropyl)-9,10-bis(methoxy-d3)-2-methyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
- 56. A compound selected from 10-methoxy-2-methyl-3-(2-methylpropyl)-9-(2,2,2-trifluoroethoxy)-1H,2H,3H,4H,6H,7H, 11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
- 58. A compound selected from 10-methoxy-2-methyl-3-(2-methylpropyl)-9-(3,3,3-trifluoropropoxy)-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
- 60. A compound selected from 3-(2,2-dimethylpropyl)-9-(3-fluoropropoxy)-10-methoxy-2-methyl-1H,2H,3H,4H,6H,7H, 11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
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62. A compound selected from 3-(2,2-dimethylpropyl)-10-methoxy-2-methyl-9-(3,3,3-trifluoropropoxy)-1H,2H,3H,4H,6H,7H, 11bH-piperazino[2,1-a]isoquinoline and pharmaceutically acceptable salts, solvates, and hydrates thereof.
Specification