NOVEL OPIOID ANTAGONISTS AND METHODS RELATED THERETO
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Abstract
Disclosed is a composition and method for a therapeutic treatment that is able to combat certain conditions such as alcohol dependence, opioid abuse treatment, neurological disorders, neuropathic pain, and fibromyalgia. The novel gliotoxin analog compound acts by acting as an antagonist to one or more opioid receptors, which, when present leads to the inhibition of conditions, providing increased performance over known treatments. The disclosed compounds also shows the ability to cross the blood-brain-barrier in a highly efficient manner.
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Citations
31 Claims
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1. (canceled)
- 2. A compound having a formula:
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3. (canceled)
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4. (canceled)
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5. (canceled)
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6. (canceled)
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7. (canceled)
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8. (canceled)
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9. (canceled)
- 10. A method for treating a disorder selected from the group consisting of alcohol dependence, opioid abuse treatment, neurological disorders, neuropathic pain, and fibromyalgia, comprising administering to a patient a therapeutically effective amount of a compound of having a formula:
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15. The method of claim 15, wherein the opioid receptor agonist is selected from the group consisting of morphine, methadone, codeine, diacetyl morphine, morphine-N-oxide, oxymorphone, oxycodone, hydromorphone, hydrocodone, meperidine, heterocodeine, fentanyl, sufentanil, levo-acetylmethadol, alfentanil, levorphanol, tilidine, diphenoxylate, hydroxymorphone, noroxymorphone, metopon, propoxyphene, and the pharmaceutically acceptable salts thereof.
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17. A method for of treating a patient comprising the step of:
- administering to a patient a pharmaceutical acceptable amount of a compound having the formula;
- View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
- administering to a patient a pharmaceutical acceptable amount of a compound having the formula;
Specification