SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK

• US 20200131200A1
• Filed: 01/10/2020
• Published: 04/30/2020
• Est. Priority Date: 01/13/2016
• Status: Active Grant

• Current Assignee: Bristol-Myers Squibb Company
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Smith, II, Leon M., Ladziata, Vladimir, De Lucca, Indawati, Pinto, Donald J.P., Orwat, Michael J., Dilger, Andrew K., Pabbisetty, Kumar Balashnmuga, Yang, Wu, Shaw, Scott A., Glunz, Peter W., Panda, Manoranjan
• Granted Patent: US 10,829,501 B2
• Time in Patent Office: Days
• CPC Class Codes: A61P 15/10 for impotence
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 213/64 attached in position 2 or 6
• CPC Class Codes: C07D 231/12 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 231/18 One oxygen or sulfur atom
• CPC Class Codes: C07D 231/54 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 239/06 having one double bond between ring members or between a ring member and a non-ring member
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07D 471/12 in which the condensed system contains three hetero rings
• CPC Class Codes: C07D 513/04 Ortho-condensed systems

Abstract

The present invention provides compounds of Formula (I):

or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Claims

1. A compound selected from the group consisting of:

N-[6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-5-methyl-1-phenyl-1H-pyrazole-4-carboxamide,

N-[6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-1-methyl-1H-indazole-3-carboxamide,

N-[6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(oxolan-3-yloxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide,

2-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

3-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyrazine-2-carboxamide,

4-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyrimidine-5-carboxamide,

2-[(6-{6-[(1,3-difluoropropan-2-yl)oxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({6-[6-(3,3,3-trifluoropropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({6-[6-(oxan-4-yloxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-2,3-dihydro-1H-indole-1-carboxamide,

N-{6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-5-cyano-2,3-dihydro-1H-isoindole-2-carboxamide,

Benzyl N-[6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]carbamate,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-5-methoxy-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-(3,3,3-trifluoropropoxy)imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)-7-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-5-[2-(morpholin-4-yl)ethoxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-[2-(pyrrolidin-1-yl)ethoxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(2,2-difluoroethoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(3,3-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(difluoromethoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-(3,3-difluoropyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-[2-(pyrrolidin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide,

methyl 3-[(3-{[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]carbamoyl}pyrazolo[1,5-a]pyridin-6-yl)oxy]azetidine-1-carboxylate,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-[(1,1-dioxo-1λ

⁶-thian-4-yl)oxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-(morpholin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(3-methanesulfonylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxyethoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(3,3,3-trifluoropropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(3,3,3-trifluoropropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-[(1,1-dioxo-1λ

⁶-thian-4-yl)oxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-7-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-5-methoxy-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-5-methanesulfonyl-2,3-dihydro-1H-indole-1-carboxamide,

2-[((aR)-6-{[(4-methoxyphenyl)carbamoyl]amino}spiro[3.3]heptan-2-yl)oxy]benzamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-7-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

4-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

3-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-4-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(2-hydroxy-2-methylpropyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-3-carboxamide,

2-({(aR)-6-[8-cyclopropyl-7-(2-fluoro-2-methylpropoxy)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

3-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridazine-4-carboxamide,

2-({(aR)-6-[7-cyclopropyl-6-(2-fluoro-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(2-hydroxy-2-methylpropyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-3-carboxamide,

2-[((aR)-6-{3-[1-(difluoromethyl)-1H-pyrazol-4-yl]-5-methanesulfonylbenzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-methanesulfonyl-5-(1-methyl-1H-pyrazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-methanesulfonyl-5-[1-(Â

²Hâ

,f)methyl-1H-pyrazol-4-yl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-(1-methyl-1H-pyrazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3′

-methanesulfonyl-[1,1′

-biphenyl]-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-bromo-5-(3,3,3-trifluoropropoxy)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(1-methyl-1H-pyrazol-4-yl)-5-(3,3,3-trifluoropropoxy)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3′

-methanesulfonyl-5-(3,3,3-trifluoropropoxy)-[1,1′

-biphenyl]-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-methoxyimidazo[1,2-b]pyridazine-2-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-chloro-8-methoxyimidazo[1,2-b]pyridazine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(2,2,2-trifluoroethoxy)imidazo[1,2-b]pyridazine-2-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-chloroimidazo[1,2-b]pyridazine-2-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N2-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}imidazo[1,2-a]pyridine-2,6-dicarboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[8-cyclopropyl-7-(2-hydroxy-2-methylpropoxy)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-methyl-1H-indazole-3-carboxamide,

N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-5-fluoro-1-(2-hydroxy-2-methylpropyl)-3a,7a-dihydro-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-methyl-1H-indazole-5-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-7-(2-oxopiperidin-1-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-methyl-1H-indole-2-carboxamide,

2-[((aR)-6-{imidazo[1,2-a]pyridine-7-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl)}quinoline-3-carboxamide,

2-{[(aR)-6-(1-phenyl-1H-pyrazole-4-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[4-(1H-pyrazol-1-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{imidazo[1,2-a]pyridine-2-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-cyanoimidazo[1,2-a]pyridine-2-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(3-tert-butyl-1-methyl-1H-pyrazole-5-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-[2-(2-methoxyethoxy)ethyl]-1H-indazole-3-carboxamide,

2-({(aR)-6-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-[2-(dimethylamino)ethoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

6-bromo-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

2-({(aR)-6-[6-(3,3,3-trifluoropropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(1,3-dimethyl-1H-pyrazole-5-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[5-(cyclopropylmethoxy)-1-methyl-1H-pyrazole-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyclopropyl-1-methyl-1H-pyrazole-5-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-methyl-5-(2,2,3,3-tetrafluoropropoxy)-1H-pyrazole-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[4-methyl-2-(pyridin-2-yl)-1,3-thiazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(1-methyl-3-phenyl-1H-pyrazole-5-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[2-(3,3-difluoroazetidin-1-yl)-4-methyl-1,3-thiazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-methyl-5-(3,3,3-trifluoropropoxy)-1H-pyrazole-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[2-(3,3-difluoropyrrolidin-1-yl)-4-methyl-1,3-thiazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

5-bromo-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

2-({(aR)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrrolo[2,3-b]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[5-(2,2-difluoroethoxy)-1-methyl-1H-pyrazole-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(4-methyl-2-phenyl-1,3-thiazole-5-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(2-hydroxy-2-methylpropyl)-6-(trifluoromethoxy)-1H-indazole-3-carboxamide,

2-({(aR)-6-[6-methoxy-7-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-methoxypyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-7-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-6-fluoro-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-2-oxo-6-(trifluoromethyl)-2,3-dihydro-1H-1,3-benzodiazole-4-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-fluoro-1-(3,3,3-trifluoropropyl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-3-carboxamide,

2-({(aR)-6-[7-cyclopropyl-6-(3,3,3-trifluoropropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-6-(2-hydroxy-2-methylpropoxy)-1H-indazole-3-carboxamide,

2-{[(aR)-6-(3-methanesulfonylbenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(4-tert-butylpyridine-2-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-6-[1-(Â

²Hâ

,f)methyl-1H-pyrazol-4-yl]-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-1H-indazole-3-carboxamide,

2-({(aR)-6-[3-tert-butyl-1-(2,2-difluoroethyl)-1H-pyrazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-tert-butyl-1-(3,3,3-trifluoropropyl)-1H-pyrazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(3,3,3-trifluoropropoxy)-7-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-(3,3,3-trifluoropropoxy)-1-(3,3,3-trifluoropropyl)-1H-indazole-3-carboxamide,

2-({(aR)-6-[6-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(3-bromo-5-methanesulfonylbenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-[((aR)-6-{6-[2-(1H-imidazol-1-yl)ethoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-[2-(2-methoxyethoxy)ethoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(4,4,4-trifluorobutoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(3-methoxy-3-methylbutoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-[3-(2-oxopyrrolidin-1-yl)propoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-[2-(trifluoromethoxy)ethoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(6-{2-[(4S)-2-oxo-1,3-oxazolidin-4-yl]ethoxy}pyrazolo[1,5-a]pyridine-3-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

2-[((aR)-6-{6-[2-(4-methyl-1,3-thiazol-5-yl)ethoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[1-(pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[2-(pyridin-2-yl)-1,3-thiazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-[methyl(phenyl)sulfamoyl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

1-benzyl-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1H-indazole-3-carboxamide,

2-({(aR)-6-[3-(2-methyl-1,3-thiazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(1H-pyrazol-1-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[2-(4-methoxyphenyl)-1,3-thiazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{2-[(propan-2-yl)sulfamoyl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-chloro-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[2-(1H-1,3-benzodiazol-2-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-[(1H-imidazol-1-yl)methyl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-[2-(4-methoxyphenyl)ethyl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[4-(1,3-benzothiazol-2-yl)-1,3-thiazole-2-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[4-(pyridin-2-yl)-1,3-thiazole-2-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[2-(1-methyl-1H-1,3-benzodiazol-2-yl)-1,3-thiazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(3-methyl-1,2,4-oxadiazol-5-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(2-chloro-4-fluoro-5-sulfamoylbenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-3-oxo-2,3-dihydrobenzo[d]isothiazole-6-carboxamide 1,1-dioxide,

2-{[(aR)-6-(4-fluoro-3-sulfamoylbenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxamide,

2-{[(aR)-6-(4-chloro-3-sulfamoylbenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-[((aR)-6-{6-chloroimidazo[1,2-a]pyridine-2-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-chloro-1-methyl-1H-indole-2-carboxamide,

2-{[(aR)-6-(5-cyano-2-fluorobenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyano-4-fluorobenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyano-5-fluorobenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyanobenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}isoquinoline-3-carboxamide,

2-[((aR)-6-{3′

-cyano-[1,1′

-biphenyl]-4-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-(4-cyanophenyl)pyridine-3-carboxamide,

2-[((aR)-6-{3′

-fluoro-[1,1′

-biphenyl]-4-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(4-methyl-2-phenyl-1,3-oxazole-5-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(5-phenyl-1,3-oxazole-4-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[7-(2-hydroxy-2-methylpropoxy)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-6-methoxypyridine-3-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-7-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-6-methoxypyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoyl-6-methoxypyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-5-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

2-[((aR)-6-{8-cyclopropylimidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

6-(benzyloxy)-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-1H-indazole-3-carboxamide,

6-bromo-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-fluoro-1-methyl-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-fluoro-1-(²H₃)methyl-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(2,2-difluoroethyl)-6-fluoro-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-fluoro-2-(²H₃)methyl-2H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-6-(3-methoxyphenyl)-1H-indazole-3-carboxamide,

2-({(aR)-6-[7-(pyrrolidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[7-(morpholin-4-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(2-methyl-1,3-thiazol-5-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-cyano-5-[1-(²H₃)methyl-1H-pyrazol-4-yl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(1,3-dimethyl-1H-pyrazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyano-5-cyclopropylbenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-[((aR)-6-{3-cyano-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(1,5-dimethyl-1H-pyrazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(2-methyl-1,3-benzothiazol-5-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-cyano-5-[1-(2-methylpropyl)-1H-pyrazol-4-yl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyano-5-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}benzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(6-cyanopyridin-3-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-cyano-5-[3-(trifluoromethyl)-1H-pyrazol-4-yl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(1-methyl-2-oxo-1,2-dihydropyridin-3-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(1-methyl-1H-pyrazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{5-cyano-3′

-methanesulfonyl-[1,1′

-biphenyl]-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(1-methyl-1H-pyrazol-5-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-cyano-5-[1-(difluoromethyl)-1H-pyrazol-4-yl]benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyano-5-{4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-yl}benzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(3-cyano-5-{5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-yl}benzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[3-cyano-5-(2-methyl-1,3-thiazol-4-yl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-[6-(2-carbamoyl-6-methoxyphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-6-methoxyphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-methoxyphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-methoxyphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4-methoxyphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4-methoxyphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-6-methylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-methylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4-methylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-methylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4-methylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(difluoromethoxy)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-chlorophenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(1H-imidazol-1-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(pyrimidin-2-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(1H-pyrazol-1-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(4-methylpiperazin-1-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(pyridin-4-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[5-(azetidin-3-yl)-2-carbamoylphenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(pyrrolidin-1-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{[2′

-(trifluoromethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-({2′

-fluoro-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(morpholin-4-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(6-fluoropyridin-2-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

methyl 5-[4-carbamoyl-3-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)phenyl]pyridine-3-carboxylate,

2-methoxyethyl N-{5-[4-carbamoyl-3-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)phenyl]pyridin-2-yl}carbamate,

N-(6-{2-carbamoyl-5-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(6-methoxypyridin-2-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[5-(6-aminopyridin-2-yl)-2-carbamoylphenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(pyridin-2-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{[3′

-(2,2,2-trifluoroethoxy)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-[6-({3′

-methoxy-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-[6-({3′

-hydroxy-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{[3′

-(difluoromethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-({3′

-fluoro-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{[3′

-(trifluoromethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-({3′

-cyano-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{[3′

-(methoxymethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{[3′

-(5-amino-4-cyano-3-methyl-1H-pyrazol-1-yl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{[3′

-(hydroxymethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(6-chloropyridin-2-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

3-[({[4′

-carbamoyl-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3-yl]methoxy}carbonyl)amino]propanoic acid,

tert-butyl 3-[({[4′

-carbamoyl-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3-yl]methoxy}carbonyl)amino]propanoate,

5-fluoro-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-N3-propyl-[1,1′

-biphenyl]-3,4′

-dicarboxamide,

N-(6-{[3′

-(aminomethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-({3′

-cyano-5′

-fluoro-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-({3′

-cyano-5′

-nitro-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

4′

-carbamoyl-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3,5-dicarboxylic acid,

N-{6-[2-carbamoyl-5-(pyridin-3-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

2-amino-2-[4′

-carbamoyl-3′

-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3-yl]acetic acid,

N-(6-{[3′

,5′

-bis(hydroxymethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-hydroxyphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{(aR)-6-[5-(3-aminoazetidin-1-yl)-2-carbamoylphenoxy]spiro[3.3]heptan-2-yl)}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{[3′

-(2-aminoethyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[3-(dimethylamino)propyl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[3-(dimethylamino)propyl]phenoxy}spiro[3.3]heptan-2-yl)-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[3-(morpholin-4-yl)propyl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[3-(morpholin-4-yl)propyl]phenoxy}spiro[3.3]heptan-2-yl)-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[3-(4-methylpiperazin-1-yl)propyl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[3-(4-methylpiperazin-1-yl)propyl]phenoxy}spiro[3.3]heptan-2-yl)-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4,6-difluorophenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4,6-difluorophenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4-fluorophenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-4-fluorophenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(5-bromo-2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-cyclopropylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[6-(2-carbamoyl-5-cyclopropylphenoxy)spiro[3.3]heptan-2-yl]-7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(1-methyl-1H-pyrazol-4-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{(aR)-6-[2-carbamoyl-5-(1-methyl-1H-pyrazol-4-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[2-carbamoyl-5-(1-cyclopropyl-1H-pyrazol-4-yl)phenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[1-(oxan-4-yl)-1H-pyrazol-4-yl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{2-carbamoyl-5-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

3-fluoro-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-4,4′

-dicarboxamide,

N-[6-(2-carbamoyl-5-{5-[(morpholin-4-yl)methyl]thiophen-2-yl}phenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

ethyl 2-[4′

-carbamoyl-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3-yl]acetate,

6-(2-hydroxy-2-methylpropoxy)-N-[6-({3′

,4′

,5′

-trifluoro-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-[6-({3′

-methanesulfonyl-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N3-[2-(dimethylamino)ethyl]-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3,4′

-dicarboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-[6-({4′

-methanesulfonyl-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-N3-methyl-[1,1′

-biphenyl]-3,4′

-dicarboxamide,

N-(6-{[3′

-(3-aminopropoxy)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3,4′

-dicarboxamide,

N-(6-{2-carbamoyl-5-[(1E)-4-hydroxybut-1-en-1-yl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

(2E)-3-[4′

-carbamoyl-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3-yl]prop-2-enoic acid,

4-fluoro-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3,4′

-dicarboxamide,

3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-N3-(2-methoxyethyl)-[1,1′

-biphenyl]-3,4′

-dicarboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{[3′

-(morpholine-4-carbonyl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

4-fluoro-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-N3-methyl-[1,1′

-biphenyl]-3,4′

-dicarboxamide,

4′

-carbamoyl-3′

-({6-[6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)-[1,1′

-biphenyl]-3-carboxylic acid,

6-(2-hydroxy-2-methylpropoxy)-N-[6-({3′

-[(2-hydroxyethyl)sulfamoyl]-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-[6-({3′

-sulfamoyl-[1,1′

-biphenyl]-4-yl}oxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(6-{[4′

-fluoro-3′

-(1H-1,2,3,4-tetrazol-5-yl)-[1,1′

-biphenyl]-4-yl]oxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[5-(3-aminopropyl)-2-carbamoylphenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{(aR)-6-[2-carbamoyl-5-(pyrrolidin-3-yl)phenoxy]spiro[3.3]heptan-2-yl)}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(5-bromo-2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(2-carbamoylphenoxy)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-{2-carbamoyl-5-[(pyrrolidin-3-yl)methyl]phenoxy}spiro[3.3]heptan-2-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-{6-[5-(4-aminobutyl)-2-carbamoylphenoxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

2-(2-aminoethoxy)-4-({6-[7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyrimidine-5-carboxamide,

2-({(aR)-6-[7-bromo-6-(2,2-difluoropropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(2,2-difluoropropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[7-cyclopropyl-6-(2,2-difluoropropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(2,2-difluoropropoxy)-7-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(difluoromethoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(2,2-difluoroethoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({6-[6-(3,3,3-trifluoro-2-hydroxypropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(4,4-difluoropiperidin-1-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(morpholin-4-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-[(3R)-3-fluoropyrrolidin-1-yl]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-7-(propan-2-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-7-methylpyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-[(3S)-3-fluoropyrrolidin-1-yl]imidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[7-(3,3-difluoropyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[7-(4,4-difluoropiperidin-1-yl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-[2-(pyrrolidin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{7-[(3R)-3-hydroxypyrrolidin-1-yl]imidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-fluoroimidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[7-(1-hydroxyethyl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-[(3R)-3-fluoropyrrolidin-1-yl]imidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-[(2R)-2-hydroxypropoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[7-(2,2-difluoroethoxy)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-[(1,3-difluoropropan-2-yl)oxy]imidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-[(2S)-2-hydroxypropoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[7-(trifluoromethyl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-methylimidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-7-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide,

2-({(aR)-6-[7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-cyclobutoxypyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-6-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

2-[((aR)-6-{7-cyclopropyl-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{7-cyclopropyl-6-[(1,3-difluoropropan-2-yl)oxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{7-cyclopropyl-6-[(oxolan-2-yl)methoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[7-cyclopropyl-6-(oxetan-3-yloxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-cyclopropyl-6-[(oxetan-2-yl)methoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{imidazo[1,2-a]pyrazine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[8-(trifluoromethyl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

methyl 3-{[3-({(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}carbamoyl)pyrazolo[1,5-a]pyridin-6-yl]oxy}azetidine-1-carboxylate,

2-[((aR)-6-{7-methoxyimidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(6-{2-oxa-6-azaspiro[3.3]heptan-6-yl}pyrazolo[1,5-a]pyridine-3-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[6-(3,3-difluorocyclobutoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-7-cyclopropyl-6-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

2-({(aR)-6-[7-cyclopropyl-6-(3-methanesulfonylpropoxy)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-cyanoimidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{8-cyanoimidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(6-{2-oxa-6-azaspiro[3.3]heptan-6-yl}pyrazolo[1,5-a]pyridine-3-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[7-(morpholin-4-yl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[7-cyclopropyl-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-[(2,2-difluoroethyl)amino]imidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[7-(3-aminoazetidin-1-yl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[7-(3,3-difluorocyclobutoxy)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{7-chloroimidazo[1,2-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-7-(1,1-dioxidothiomorpholino)imidazo[1,2-a]pyridine-3-carboxamide,

2-[((aR)-6-{6-[1-(²H₃)methyl-1H-pyrazol-4-yl]-[1,2,3]triazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(1-cyclopropyl-1H-pyrazol-4-yl)-[1,2,3]triazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-[1,2,3]triazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{6-[1-(propan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-[1,2,3]triazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,3]triazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{6-bromo-[1,2,3]triazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(morpholin-4-yl)-[1,2,3]triazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[7-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)imidazo[1,2-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyrazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(difluoromethyl)-6-(morpholin-4-yl)-1H-indazole-3-carboxamide,

2-({(aR)-6-[6-(benzyloxy)-7-chloro-[1,2,3]triazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(benzyloxy)-7-cyclopropyl-[1,2,3]triazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-[1,2,3]triazolo[1,5-a]pyridine-3-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

6-(benzyloxy)-N-((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)-5-chloro-3-cyclopropylindolizine-1-carboxamide,

2-({(aR)-6-[1-(4-bromophenyl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{5-methyl-1-[4-(morpholin-4-yl)phenyl]-1H-pyrazole-4-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-{[(aR)-6-(5-methyl-1-phenyl-1H-pyrazole-4-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-[((aR)-6-{7-methoxy-1-methyl-1H,4H,5H-benzo[g]indazole-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{7-methoxy-2-methyl-2H,4H,5H-benzo[g]indazole-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{1-[(4-fluorophenyl)methyl]-3-methyl-1H-pyrazole-4-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{1-[(4-fluorophenyl)methyl]-5-methyl-1H-pyrazole-4-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-(4-cyanophenyl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{5-methyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[1-(4-methanesulfonylphenyl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-(4-cyano-2-fluorophenyl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(1-phenyl-1H-1,2,3-triazole-4-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-{[(aR)-6-(2-phenyl-1H-imidazole-4-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[1-(4-cyano-3-fluorophenyl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(2,5-dimethyl-1-phenyl-1H-imidazole-4-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[1-(3-chloro-2-fluorophenyl)-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-(3-chlorophenyl)-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-(3-methoxyphenyl)-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(1-methyl-5-phenyl-1H-pyrazole-3-amido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[1-(2-chlorophenyl)-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-(2-methoxyphenyl)-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-(3-cyanophenyl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[1-(6-methoxypyridin-3-yl)-5-methyl-1H-pyrazole-4-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(1-cyano-1-methylethyl)-6-fluoro-1H-indazole-3-carboxamide,

1-(1-carbamoyl-1-methylethyl)-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-fluoro-1H-indazole-3-carboxamide,

6-bromo-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(1-cyano-1-methylethyl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-[(3,3-difluoro-1-hydroxycyclobutyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-[(1-hydroxycyclobutyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(1-cyano-1-methylethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(1-cyano-1-methylethyl)-6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-1H-indazole-3-carboxamide,

1-(1-carbamoyl-1-methylethyl)-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-3-carboxamide,

1-(1-carbamoyl-1-methylethyl)-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-1H-indazole-3-carboxamide,

1-(1-carbamoyl-1-methylethyl)-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-(3,3,3-trifluoropropoxy)-1H-indazole-3-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-(1-cyano-1-methylethyl)-6-(3,3,3-trifluoropropoxy)-1H-indazole-3-carboxamide,

1-(1-carbamoyl-1-methylethyl)-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-6-(2-hydroxy-2-methylpropoxy)-1H-indazole-3-carboxamide,

2-[((aR)-6-{6-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-[((aR)-6-{7-cyclopropyl-6-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(benzyloxy)-3-[(dimethylamino)methyl]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{2-[4-(cyclopropanesulfonyl)phenyl]-1,3-thiazole-5-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[2-(4-cyanophenyl)-1,3-thiazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{2-[3-fluoro-4-(methylcarbamoyl)phenyl]-1,3-thiazole-5-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[2-(3-cyanophenyl)-1,3-thiazole-5-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-bromoimidazo[1,5-a]pyridine-1-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(3-tert-butylbenzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

6-bromo-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-2-methyl-2H-indazole-4-carboxamide,

6-bromo-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-1-methyl-1H-indazole-4-carboxamide,

N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}-2-oxo-6-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazine-8-carboxamide,

2-({(aR)-6-[3-bromo-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-bromo-3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(benzyloxy)-3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

1-({(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}carbamoyl)-3-(trifluoromethyl)imidazo[1,5-a]pyridin-6-yl trifluoromethanesulfonate,

2-({(aR)-6-[6-(1-methyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(2-hydroxy-2-methylpropoxy)-3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(benzyloxy)-3-(difluoromethyl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-(2-methyl-1,3-thiazol-5-yl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-(1-methyl-1H-imidazol-5-yl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-(morpholin-4-yl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-(3-hydroxy-3-methylbutoxy)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-[(2-hydroxy-2-methylpropyl)amino]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-[(2-hydroxy-2-methylpropyl)amino]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(2-methyl-1,3-thiazol-5-yl)-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-[((aR)-6-{3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-5-(trifluoromethyl)benzamido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[3-(1,3-dimethyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(1-methyl-1H-imidazol-5-yl)-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(4-hydroxy-4-methylpiperidin-1-yl)-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-[2-(2-hydroxyethyl)morpholin-4-yl]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(3-{2-oxa-5-azabicyclo[2.2.1]heptan-5-yl}-5-(trifluoromethyl)benzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-[(N-methylacetamido)methyl]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(1,5-dimethyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)benzamido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-(difluoromethyl)-6-[(3S)-3-(hydroxymethyl)piperazin-1-yl]imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-{[(aR)-6-(3-{8-oxa-3-azabicyclo[3.2.1]octan-3-yl}-5-(trifluoromethyl)benzamido)spiro[3.3]heptan-2-yl]oxy}pyridine-3-carboxamide,

2-[((aR)-6-{6-bromo-3-methylimidazo[1,5-a]pyridine-1-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[6-(1,5-dimethyl-1H-pyrazol-4-yl)-3-methylimidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[6-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methylimidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-({(aR)-6-[3-methyl-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,5-a]pyridine-1-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide,

2-amino-N-{(aR)-6-[(3-carbamoylpyridin-2-yl)oxy]spiro[3.3]heptan-2-yl}) quinazoline-4-carboxamide,

2-[((aR)-6-{7-cyclopropyl-6-[(1-hydroxycyclobutyl)methoxy]pyrazolo[1,5-a]pyridine-3-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide,

2-({(aR)-6-[7-(benzyloxy)imidazo[1,2-a]pyridine-2-amido]spiro[3.3]heptan-2-yl}oxy)pyridine-3-carboxamide, and

2-[((aR)-6-{6-methoxyimidazo[1,2-a]pyridine-2-amido}spiro[3.3]heptan-2-yl)oxy]pyridine-3-carboxamide, or a pharmaceutically acceptable salt.

2. A pharmaceutical composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier or diluent.

3. A method for prophylaxis and/or treatment of a disorder associated with aberrant Rho kinase activity, comprising administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition according to claim 2.

4. The method according to claim 3, wherein said disorder is selected from the group consisting of a cardiovascular disorder, a smooth muscle related disorder, a fibrotic disease, an inflammatory disease, a neuropathic disorder, an oncologic disorder, and an autoimmune disorder.

5. The method according to claim 4, wherein said cardiovascular disorder is selected from the group consisting of angina, atherosclerosis, stroke, cerebrovascular disease, heart failure, coronary artery disease, myocardial infarction, peripheral vascular disease, stenosis, vasospasm, hypertension and pulmonary hypertension.