TYK2 INHIBITORS AND USES THEREOF

• US 20200131201A1
• Filed: 10/15/2019
• Published: 04/30/2020
• Est. Priority Date: 10/15/2018
• Status: Active Grant

• Current Assignee: Takeda Pharmaceutical Company Limited
• Original Assignee: Nimbus Lakshmi Inc. (Takeda Pharmaceutical Company Limited)
• Inventors: Masse, Craig E., Greenwood, Jeremy Robert, Mondal, Sayan
• Granted Patent: US 11,414,431 B2
• Time in Patent Office: Days
• CPC Class Codes: C07D 487/04 Ortho-condensed systems
• CPC Class Codes: C07D 519/00 Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Claims

1. A compound of Formula I′

;

2. The compound of claim 1 of Formulae II or IV:

3. The compound of claim 1 of Formulae III or V:

5. The compound of claim 1 of Formula VII:

6. The compound of claim 1 of Formula VIII:

7. The compound of claim 1, wherein R^1A is selected from:

8. The compound of claim 7, wherein R^2A is selected from:

9. The compound of claim 1, seleceted from

12. A method of inhibiting TYK2 in a biological sample comprising contacting the sample with the compound of claim 1, or a pharmaceutically acceptable salt thereof.

4. The compound of claim of Formula VI:

15-31. -31. (canceled)