SIALIC ACID ANALOGS
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Abstract
The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
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Citations
97 Claims
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1-77. -77. (canceled)
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78. A compound selected from the group consisting of:
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79. The compound of claim 78, wherein the compound is:
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80. The compound of claim 78, wherein the compound is:
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81. The compound of claim 78, wherein the compound is:
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82. The compound of claim 78, wherein the compound is:
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83. The compound of claim 78, wherein the compound is:
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84. The compound of claim 78, wherein the compound is:
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85. A pharmaceutical composition comprising a compound selected from the group consisting of:
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86. The pharmaceutical composition of claim 85, comprising the compound:
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87. The pharmaceutical composition of claim 85, comprising the compound:
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88. The pharmaceutical composition of claim 85, comprising the compound:
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89. The pharmaceutical composition of claim 85, comprising the compound:
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90. The pharmaceutical composition of claim 85, comprising the compound:
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91. The pharmaceutical composition of claim 85, comprising the compound:
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92. A sustained release pharmaceutical composition comprising a compound of claim 78, or a pharmaceutically acceptable salt or solvate thereof, wherein:
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a) the release of the compound is over a period of about four hours or more; and
/orb) the pharmacological effect from the compound lasts about four hours or more upon administration of the composition.
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93. A sustained release pharmaceutical composition comprising a compound of claim 78, or a pharmaceutically acceptable salt or solvate thereof,
wherein the composition, upon administration, provides a therapeutically effective amount of the compound for about 4 hours or more.
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94. A method for treating a sialic acid deficiency in a patient in need thereof comprising administering an effective amount of a compound of claim 78, or a pharmaceutically acceptable salt or solvate thereof.
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95. A method for treating a sialic acid deficiency in a patient in need thereof comprising administering a compound of claim 78, or a pharmaceutically acceptable salt or solvate thereof;
- wherein upon administration, the compound, or a pharmaceutically acceptable salt or solvate thereof, continuously provides a therapeutically effective amount of sialic acid for about 4 hours to about 24 hours.
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96. The method of claim 94, wherein the sialic acid deficiency is myopathy associated with sialic acid deficiency.
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97. The method of claim 96, wherein the myopathy associated with sialic acid deficiency is Hereditary Inclusion Body Myopathy (HIBM), Nonaka myopathy, or Distal Myopathy with Rimmed Vacuoles (DMRV).
Specification