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Methods and Compositions for Promoting Immune Cell Function

  • US 20200131239A1
  • Filed: 06/13/2017
  • Published: 04/30/2020
  • Est. Priority Date: 06/13/2016
  • Status: Active Grant
First Claim
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1. A composition comprising a nucleated cell and a nanoparticle that comprises at least one conservation agent, wherein:

  • (a) at least part of the composition is frozen,(b) the conservation agent comprises a cytokine molecule or a costimulatory molecule, and(c) wherein;

    (i) the cytokine molecule is chosen from IL15, IL2, IL6, IL7, IL12, IL17, IL18, IL21, IL-23, IL-4, IL1alpha, IL1beta, IL-5, IFNgamma, TNFa, IFNalpha, IFNbeta, GM-CSF, or GCSF; and

    /or(ii) the costimulatory molecule is chosen from an, OX40, CD28, GITR, VISTA, CD40, CD3, or an agonist of CD137.

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