ANTI-PACAP ANTIBODY
First Claim
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1. A pharmaceutical composition comprising:
- an antibody that binds human pituitary adenylate cyclase-activating peptide comprising a heavy chain variable region (HCVR) and a light chain variable region (LCVR), wherein the HCVR comprises complementarily determining regions (CDRs) HCDR1, HCDR2, and HCDR3 and the LCVR comprises CDRs LCDR1, LCDR2, and LCDR3, wherein the amino acid sequence of HCDR1 is SEQ ID NO.3, the amino acid sequence of HCDR2. is SEQ ID NO.4, the amino acid sequence of HCDR3 is SEQ ID NO.5, the amino acid sequence of LCDR1 is SEQ ID NO.6, the amino acid sequence of LCDR2 is SEQ ID NO.7, and the amino acid sequence of LCDR3 is SEQ ID NO.8, wherein HCDR2 comprises aspartic acid, alanine, glutamic acid or glutamine at residue 13 of SEQ ID. NO. 4, HCDR3 comprises asparagine or threonine at residue 8 of SEQ ID NO. 5, LCDR1 comprises serine or tryptophan at residue 7 of SEQ ID NO. 6, LCDR2 comprises leucine or phenylalanine at residue 7 of SEQ ID NO. 7; and
one or more pharmaceutically acceptable carriers, diluents or excipients.
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Abstract
Antibodies to human pituitary adenylate cyclase-activating peptide, compositions comprising such antibodies, and methods of using such antibodies for the treatment of pain including headache and/or migraine.
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18 Claims
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1. A pharmaceutical composition comprising:
an antibody that binds human pituitary adenylate cyclase-activating peptide comprising a heavy chain variable region (HCVR) and a light chain variable region (LCVR), wherein the HCVR comprises complementarily determining regions (CDRs) HCDR1, HCDR2, and HCDR3 and the LCVR comprises CDRs LCDR1, LCDR2, and LCDR3, wherein the amino acid sequence of HCDR1 is SEQ ID NO.3, the amino acid sequence of HCDR2. is SEQ ID NO.4, the amino acid sequence of HCDR3 is SEQ ID NO.5, the amino acid sequence of LCDR1 is SEQ ID NO.6, the amino acid sequence of LCDR2 is SEQ ID NO.7, and the amino acid sequence of LCDR3 is SEQ ID NO.8, wherein HCDR2 comprises aspartic acid, alanine, glutamic acid or glutamine at residue 13 of SEQ ID. NO. 4, HCDR3 comprises asparagine or threonine at residue 8 of SEQ ID NO. 5, LCDR1 comprises serine or tryptophan at residue 7 of SEQ ID NO. 6, LCDR2 comprises leucine or phenylalanine at residue 7 of SEQ ID NO. 7; and
one or more pharmaceutically acceptable carriers, diluents or excipients.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 6, 16, 17, 18)
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11. A pharmaceutical composition comprising an antibody that binds human pituitary adenylate cyclase-activating peptide comprising a heavy chain (HC) and a light chain (LC), wherein the amino acid sequence of the HC is SEQ ID NO.1 and the amino acid sequence of the LC is SEQ NO.2;
- and one or more pharmaceutically acceptable carriers, diluents or excipients.
- View Dependent Claims (12, 13, 14, 15)
Specification