POLYMER PARTICLES

• US 20200131287A1
• Filed: 11/22/2019
• Published: 04/30/2020
• Est. Priority Date: 11/08/2013
• Status: Active Grant

• Current Assignee: Terumo Corporation
• Original Assignee: Terumo Corporation
• Inventors: Plotkin, Steve, Cruise, Gregory M., Keeley, Edward Michael, Yu, Renee, Harris, Clayton
• Granted Patent: US 11,261,274 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/146 with organic macromolecular compounds
• CPC Class Codes: A61K 9/5026 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: C08F 16/06 Polyvinyl alcohol ; Vinyl alcohol
• CPC Class Codes: C08F 20/28 containing no aromatic rings in the alcohol moiety
• CPC Class Codes: C08F 20/38 Esters containing sulfur
• CPC Class Codes: C08F 20/56 Acrylamide; Methacrylamide
• CPC Class Codes: C08F 22/385 Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
• CPC Class Codes: C08F 220/10 Esters
• CPC Class Codes: C08F 220/20 of polyhydric alcohols or phenols , e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
• CPC Class Codes: C08F 220/28 containing no aromatic rings in the alcohol moiety
• CPC Class Codes: C08F 220/282 and containing two or more oxygen atoms
• CPC Class Codes: C08F 220/38 Esters containing sulfur
• CPC Class Codes: C08F 220/382 and containing oxygen, e.g. 2-sulfoethyl (meth)acrylate
• CPC Class Codes: C08F 290/062 Polyethers
• CPC Class Codes: C08G 65/33324 : acyclic
• CPC Class Codes: Y10T 428/2982 : Particulate matter [e.g., sphere, flake, etc.]

Abstract

Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

Claims

1. A polymer particle comprising:

a poly(ethylene glycol) macromer,

a first monomer; and

a second monomer configured to allow biding of positively charged drugs, wherein the second monomer is selected from acrylic acid, methacrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;

wherein the polymer particle is spherical.

2. The polymer particle of claim 1, wherein the polymer particle has a diameter between about 40 μ

m and about 1,200 μ

m.

3. The polymer particle of claim 1, wherein the polymer particle has a diameter less than about 1,200 μ

m.

4. The polymer particle of claim 1, wherein the first monomer includes a functional group.

5. The polymer particle of claim 4, wherein the functional group is an acrylate, an acrylamide, a methacrylate, or a methacrylamide.

6. The polymer particle of claim 1, wherein the first monomer is glycerol monomethacrylate, amino ethyl methacrylate, amino propyl methacrylate, or a combination thereof.

7. The polymer particle of claim 1, wherein the poly(ethylene glycol) macromer is poly(ethylene glycol) diacrylamide.

8. The polymer particle of claim 7, wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.

9. The polymer particle of claim 1, wherein the poly(ethylene glycol) macromer is at a concentration of about 28% w/w.

10. A polymer particle comprising:

a poly(ethylene glycol) macromer,

a first monomer; and

a second monomer configured allow biding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;

wherein the polymer particle is spherical.

11. The polymer particle of claim 10, wherein the polymer particle has a diameter between about 40 μ

m and about 1,200 μ

m.

12. The polymer particle of claim 10, wherein the polymer particle has a diameter less than about 1,200 μ

m.

13. The polymer particle of claim 10, wherein the first monomer includes a functional group.

14. The polymer particle of claim 13, wherein the functional group is an acrylate, an acrylamide, a methacrylate, or a methacrylamide.

15. The polymer particle of claim 10, wherein the first monomer is glycerol monomethacrylate, 3-sulfopropyl acrylate, or a combination thereof.

16. The polymer particle of claim 10, wherein the poly(ethylene glycol) macromer is poly(ethylene glycol) diacrylamide.

17. The polymer particle of claim 16, wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.

18. The polymer particle of claim 10, wherein the poly(ethylene glycol) macromer is at a concentration of about 28% w/w.

19. A kit comprising:

a plurality of polymer particles in a container,

wherein the plurality of polymer particles comprise a reaction product of;

a poly(ethylene glycol) macromer,

a first monomer; and

a second monomer configured to allow biding of positively charged drugs, wherein the second monomer is selected from acrylic acid, methacrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;

wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μ

m.

20. A kit comprising:

a plurality of polymer particles in a container,

wherein the plurality of polymer particles comprise a reaction product of;

a poly(ethylene glycol) macromer,

a first monomer; and

a second monomer configured allow biding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;

wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μ

m.