Method For Enhancing Proliferation Capability Of Stem Cells Using Ethionamide

• US 20200131480A1
• Filed: 09/28/2017
• Published: 04/30/2020
• Est. Priority Date: 10/24/2016
• Status: Abandoned Application

• Current Assignee: Samsung Life Insurance Company Limited (Samsung Group)
• Original Assignee: Samsung Life Insurance Company Limited (Samsung Group)
• Inventors: NA, Duk Lyul, CHANG, Jong Wook, SON, Hyo Jin, MYEONG, Su Hyeon
• Application Number:
  US16/627,875
• Publication Number:
  US 20200131480A1
• Time in Patent Office: Days
• CPC Class Codes: C12N 2500/30 Organic components metal chelators C12N2500/10; calcitonin C12N2500/14; transferrin C12N2500/24
• CPC Class Codes: C12N 2501/999 Small molecules not provided for elsewhere
• CPC Class Codes: C12N 5/0665 Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
• CPC Class Codes: C12N 5/0668 Mesenchymal stem cells from other natural sources

Abstract

The present disclosure relates to a medium composition for enhancing proliferation of stem cells, comprising ethionamide, and a use thereof. It is possible, according to the present disclosure, to mass-produce highly-efficient next-generation stem cells through a simple and safe method of controlling a culturing environment, without using genetic modification or viral vectors, etc.

Claims

1. A medium composition for enhancing the proliferation of stem cells, comprising ethionamide.

2. The medium composition of claim 1, wherein the ethionamide is included at a concentration of 1 to 500 μ

M in a medium.

3. The medium composition of claim 1, wherein the medium is an α

-minimum essential media (α

-MEM) medium supplemented with fetal bovine serum (FBS) and gentamicin.

4. The medium composition of claim 1, wherein the stem cells are embryonic stem cells or adult stem cells.

5. The medium composition of claim 4, wherein the adult stem cells are mesenchymal stem cells derived from one or more tissues selected from the group consisting of an umbilical cord, umbilical cord blood, bone marrow, fat, muscle, nerve, skin, an amniotic membrane, and a placenta.

6. A method for enhancing the proliferation of stem cells, comprising:

culturing stem cells in the medium composition defined in claim 1.

7. The method of claim 6, wherein the stem cells are mesenchymal stem cells derived from one or more tissues selected from the group consisting of an umbilical cord, umbilical cord blood, bone marrow, fat, muscle, nerve, skin, an amniotic membrane, and a placenta.

8. Stem cells having an enhanced proliferation capability, obtained by the method defined in claim 6.

9. The stem cells of claim 8, wherein the stem cells are mesenchymal stem cells derived from one or more tissues selected from the group consisting of an umbilical cord, umbilical cord blood, bone marrow, fat, muscle, nerve, skin, an amniotic membrane, and a placenta.