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METHOD FOR ISOLATING CROSS-REACTIVE APTAMER AND USE THEREOF

  • US 20200131514A1
  • Filed: 10/30/2018
  • Published: 04/30/2020
  • Est. Priority Date: 10/30/2018
  • Status: Active Grant
First Claim
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1. A method for isolating a cross-reactive aptamer for synthetic cathinones, the method comprising:

  • providing a DNA library;

    selecting at least three synthetic cathinone targets;

    performing at least one round of parallel selection against each selected synthetic cathinone target to isolate a pool of aptamers for each selected synthetic cathinone target;

    performing at least one cycle of serial selection against each selected synthetic cathinone target in each round sequentially; and

    collecting the cross-reactive aptamer.

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