GENETIC VARIANTS ASSOCIATED WITH HUMAN-DIRECTED HYPER-SOCIAL BEHAVIOR IN DOMESTIC DOGS
First Claim
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1. A method for predicting the probability of a canine exhibiting a sociable behavior comprising:
- (a) genotyping a biological sample from a canine;
(b) counting the number of structural variants within the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6; and
(c) predicting the probability of the canine exhibiting a sociable behavior based on the number of structural variants.
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Abstract
Disclosed herein are structural variants in the Williams-Beuren Syndrome locuse of the dog genome that are associated with hyper-social behavior in dogs relative to wolves, and that are informative regarding the nature of social behavior in dogs. Disclosed also is a commercial test with these loci as indicators along the spectrum of sociality. Methods of breeding dogs to select for dogs having increased sociability are also disclosed.
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Citations
38 Claims
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1. A method for predicting the probability of a canine exhibiting a sociable behavior comprising:
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(a) genotyping a biological sample from a canine; (b) counting the number of structural variants within the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6; and (c) predicting the probability of the canine exhibiting a sociable behavior based on the number of structural variants.
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2. A method of ranking dogs or wolves according to their likely level of exhibiting a sociable behavior comprising:
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(a) obtaining a biological sample from a first dog or wolf; (b) determining the number of structural variants within the Williams-Beuren Syndrome (WBS) locus on chromosome 6 of the first dog or wolf; (c) obtaining a biological sample from a second dog or wolf; (d) determining the number of structural variants within the Williams-Beuren Syndrome (WBS) locus on chromosome 6 of the second dog or wolf; and (e) ranking the first dog as being more likely to exhibit a sociable behavior than the second dog if the number of structural variants determined in step (b) is greater than the number of structural variants determined in step (d);
or(f) ranking the second dog as being more likely to exhibit a sociable behavior than the first dog if the number of structural variants determined in step (d) is greater than the number of structural variants determined in step (b). - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of screening a dog or wolf library comprising:
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(a) obtaining a genomic library from a dog or wolf that contains the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6; (b) determining the number of structural variants in the WBS locus. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method of producing dogs that are more likely to exhibit a sociable behavior comprising:
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(a) selecting a male and female dog for breeding that each are known to have at least one structural variant within Cfa6.6, Cfa6.7, Cfa6.66, or Cfa6.83 in the Williams-Beuren Syndrome (WBS) locus; and (b) mating the dogs of step (a) to produce offspring. - View Dependent Claims (26, 27)
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28. A method of editing the genome of a dog comprising:
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(a) obtaining a dog; (b) using clustered regularly interspaced short palindromic repeats (CRISPRs)/CRISPR-associated (Cas) 9 to inactivate a gene in the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6. - View Dependent Claims (29)
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- 30. A kit for detecting the presence of structural variants within the Williams-Beuren Syndrome (WBS) locus of canines comprising one or more primers selected from the group consisting of:
Specification