DIGITAL THERAPEUTICS AND BIOMARKERS WITH ADJUSTABLE BIOSTREAM SELF-SELECTING SYSTEM (ABSS)

• US 20200131581A1
• Filed: 10/26/2018
• Published: 04/30/2020
• Est. Priority Date: 10/26/2018
• Status: Active Grant

• Current Assignee: Vignet Incorporated (Vignet IT Solutions Pvt Ltd.)
• Original Assignee: Vignet Incorporated (Vignet IT Solutions Pvt Ltd.)
• Inventors: Jain, Praduman, Schilling, Josh, Klein, Dave, Jain, Neeta, Cao, Yue
• Granted Patent: US 11,158,423 B2
• Time in Patent Office: Days
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 40/20 for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16H 80/00 ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring

Abstract

A system and method for an adjustable bio-stream self-selecting system. Through a plethora of inputs, the system associates therapeutic recipes and associated biomarker in a personalized approach to recommending an individual to a specific therapeutic program. Therapeutic programs operate in accordance with personalized inputs suggested by the user and through digital markers and biomarkers, which trigger new recommendations by “knowing” the individual. Each bio-stream contains information utilized within these biomarkers to trigger additional therapy recommendations. Because of the complexity of the plurality of inputs, these biomarkers are managed in a way that enables low latency detections, low bandwidth needs, low processing needs, and less battery needs. The pre-processing of these biomarkers helps additional therapy management and precision medicine across larger global population needs of the system.

Claims

1. A system of networked devices that provide adaptive therapeutic plans, the processing being performed over a network to provide communication interface amongst the networked devices, the system comprising:

the network over which a plurality of networked devices communicate;

a server processor device within the network, wherein the server processor device includes a set of server instructions on a non-transitory server processor memory, when executed by the server processor device, configure the server processor device to;

receive input from a user of an application resident on a client processor device, wherein the input is used by the server processor device to select a therapeutic plan;

transmit the therapeutic plan to the client processor device, wherein the therapeutic plan includes a subset of data source configurations;

a client processor device having a comparator portion, a controller portion, and a configuration profile manager portion, wherein the client processor device includes a set of client instructions on a non-transitory client device memory, the set of client instructions, when executed by the client processor device, configure the client device to;

update the application on the client processor device with the therapeutic plan;

activate the configuration profile manager portion, wherein the configuration profile manager portion selects a data configuration profile from a plurality of data configuration profiles on the client processor device based on the selected therapeutic plan and the subset of data source configurations;

activate the controller portion, wherein the controller portion controls the precision of at least one data source from a plurality of data sources available to the client processor device based on the selected data configuration profile;

activate a comparator portion, wherein the comparator portion combines data from the controller portion;

receive a plurality of informatic data from at least one data source and using the selected data configuration profile and the at least one controller to generate at least one personalized observed data instance; and

process the at least one personalized observed data instance through the comparator to adapt the therapeutic plan to a personalized therapeutic plan.

2. The system of claim 1, wherein the client device is in bi-directional communication with the plurality of data sources.

3. The system of claim 1, wherein the plurality of data sources includes at least one sensor.

4. The system of claim 3, wherein the controller controlling the at least one data source comprises activating at least one sensor.

5. The system of claim 3, the controller controlling the at least one data signal by controlling the at least one sensor by deactivating the sensor.

6. The system of claim 1, the controller controlling the at least one data signal in the form of at least one configured biostream signal by at least one of smoothing the biostream signal, generating a signal derivative, or detecting signal peaks.

7. The system of claim 1, wherein the plurality of data sources is comprised of at least one of a directly observed data source, a passively observed data source, an indirectly observed data source, a publicly observed data source, or a comparatively observed data source.

8. A method for dynamically adapting and displaying at least one therapeutic plan on a recipient processor device within a network of a plurality of connected devices, the method comprising:

receiving, by a server processor device, input from the recipient processor device of a user of a therapeutic application resident on the recipient processor device;

selecting, by a server processor device, at least one therapeutic plan based on the input received from the recipient processor device;

transmitting the at least one therapeutic plan to the recipient processor device, wherein the therapeutic plan includes a subset of data source configurations;

receiving, by the recipient processor device, the at least one therapeutic plan and updating the therapeutic application resident on the recipient processor device with the at least one therapeutic plan;

activating, by the recipient processor device, a configuration profile manager for managing the selection of a data configuration profile from a plurality of data configuration profiles resident on the recipient processor device, wherein the selected data configuration profile manager is determined based on the at least one therapeutic plan and the subset of data source configurations;

activating, by the recipient processor device, at least one controller for controlling the precision of at least one data source from a plurality of data sources based on the selected data configuration profile;

activating, by the recipient processor device, a comparator for combining data from the at least one controller;

observing a plurality of informatic data from at least one data source from the plurality of data sources and using the selected data configuration profile and the at least one controller to generate at least one observed data instance;

processing the at least one observed data instance through the comparator to generate at least one combined data instance;

adapting, by the recipient processor device, the at least one selected therapeutic plan on the recipient processor device to the at least one personalized therapeutic plan based on the at least one combined data instance.

9. The method of claim 8, further including the recipient processor device communicating in bi-directional communication with the plurality of data sources.

10. The method of claim 8, wherein the plurality of data sources includes at least one sensor.

11. The method of claim 10, wherein controlling the at least one data source comprises activating at least one sensor.

12. The method of claim 10, the controller controlling the at least one data signal by controlling the at least one sensor by deactivating the sensor.

13. The method of claim 8, controlling the at least one data signal in the form of at least one configured biostream signal by at least one of smoothing the biostream signal, generating a signal derivative, or detecting signal peaks.

14. The method of claim 8, wherein the plurality of data sources is comprised of at least one of a directly observed data source, a passively observed data source, an indirectly observed data source, a publicly observed data source, or a comparatively observed data source.

15. A device for dynamically adapting and displaying at least one personalized therapeutic plan, comprising:

a processor including instructions on a non-transitory computer medium, the non-transitory computer medium constituted by one or more data storage mediums;

the instructions, when executed by the processor, configures the recipient device to;

activate at least one controller for controlling the precision of at least one data signal from a plurality of data sources;

activate a biostream comparator for combining data from the at least one controller;

a therapeutic plan resident on device and associated with a user of the device;

a plurality of biomarker configuration profiles resident on the device;

activate a biomarker configuration profile manager, the biomarker configuration profile manager using the therapeutic plan to select one of the plurality of biomarker configuration profiles;

initialize the device to observe a plurality of bioinformatic data from the plurality of data sources and using the selected biomarker configuration profile and the at least one controller to generate at least one configured biostream;

process the at least one configured biostream through the comparator to generate at least one biomarker; and

updating, by a therapeutic plan manager, the at least one personalized therapeutic plan based on the at least one biomarker.

16. The device of claim 15, the updating of the at least one personalized therapeutic plan entails the therapeutic plan manager selecting a new therapeutic plan.

17. The device of claim 15, the updating of the at least one personalized therapeutic plan entails modifying the therapeutic plan.

18. The device of claim 15, the device in bi-directional communication with the plurality of data sources.

19. The device of claim 15, the plurality of data sources includes at least one sensor

20. The device of claim 19, the selected biomarker configuration profile interacting with the controller to control the at least one sensor.

21. The device of claim 20, the controller controlling the at least one sensor by activating the sensor.

22. The device of claim 20, the controller controlling the at least one sensor by deactivating the sensor.

23. The device of claim 15, the controller controlling the at least one data signal in the form of at least one configured biostream signal by at least one of smoothing the biostream signal, generating a signal derivative, or detecting signal peaks.

24. The device of claim 15, the at least one personalized therapeutic plan resident on the device being selected by a user during initialization.

25. The device of claim 15, the at least one personalized therapeutic plan resident on the device being selected by the processor during initialization.

26. The device of claim 15, the at least one biomarker used to configure an application configuration profile comprising at least one therapeutic application module.

27. The device of claim 15, the at least one biomarker used to instruct a therapeutic module manager to configure an application with at least one therapeutic application module.

28. The device of claim 15, the plurality of data sources comprised of at least one of a directly observed data source, a passively observed data source, an indirectly observed data source, a publicly observed data source, or a comparatively observed data source.

29. The device of claim 15, the at least one personalized therapeutic plan being a plan for treating cancer.

30. The device of claim 15, the at least one biomarker is indicative of cancer.