ION MOBILITY DEVICES AND METHODS

• US 20200132627A1
• Filed: 06/14/2018
• Published: 04/30/2020
• Est. Priority Date: 06/14/2017
• Status: Abandoned Application

• Current Assignee: Ion Dx, Inc.
• Original Assignee: Ion Dx, Inc.
• Inventors: Benner, W. Henry, Bogan, Michael J.
• Application Number:
  US16/622,149
• Publication Number:
  US 20200132627A1
• Time in Patent Office: Days
• CPC Class Codes: G01N 27/622 Ion mobility spectrometry
• CPC Class Codes: G01N 27/623 combined with mass spectrometry
• CPC Class Codes: H01J 49/28 Static spectrometers

Abstract

Methods of ion mobility spectrometry are provided in which a sample material is modified by exposing the sample material to physical stress to produce a modified material, ions are generated from the modified material to produce generated ions, the generated ions are separated to produce separated ions and the separated ions are detected. The modified material is delivered to an electrospray generator and are separated and detected. Embodiments of the invention modify the ions after they are generated. After detection, the data is processed mathematically to produce processed data that is recognized by experts in the field of ion mobility spectrometry. Apparatuses are provided to carry out the methods.

Claims

1. A method, comprising:

providing a sample material;

modifying said sample material by exposing said sample material to physical stress to produce a modified material;

generating ions from said modified material to produce generated ions;

separating said generated ions to produce separated ions; and

detecting said separated ions.

2. The method of claim 1, wherein the step of exposing said sample material to physical stress comprises exposing said sample material to at least one of heat, cold, light or a chemical reagent.

5. The method of claim 1, wherein said sample material is constantly exposed to said physical stress by a steadily-changing process.

7. The method of claim 1, wherein said sample material is in the liquid phase, wherein the step of modifying said sample material includes pumping said sample through a capillary, wherein the step of pumping said sample material through a capillary comprises:

providing a chamber;

locating said sample material in said chamber, wherein an end of said capillary is located in said sample material; and

providing pressure and heat to said chamber, wherein said sample material is heated to produce said modified material and wherein said pressure forces a portion of said modified material to flow through said capillary and out of said chamber.

11. The method of claim 1, wherein said sample is in the liquid phase, wherein the step of modifying said sample material includes pumping said sample through a capillary, wherein said sample material is pumped by a pumping mechanism selected from the group consisting of a syringe pump, a micro-fluidics pump and a liquid chromatography system, wherein the step of modifying said sample material includes introducing a flow of a liquid chemical into said capillary.

16. The method of claim 1, wherein the step of modifying said sample material includes the use of tunable laser radiation to impart thermal, oxidative or bond-breaking stress to said sample material.

18. The method of claim 1, wherein said modified material is conducted to an electrospray generator to produce said generated ions, wherein stable delivery of gases is provided to said electrospray generator by using mass flow controllers that are accurate to +/−

2% of the full-scale flowrate so that accurate quantitation of the electro-sprayed ion concentration can be obtained.

20. The method of claim 18, further comprising operatively locating a camera for producing images of the ion generating process, further comprising processing said images with image recognition software, along with a sensor to monitor the electrospray current, as a means to provide feedback to the electrospray process for the purpose of improving the stability of the electrospray process.

31. The method of claim 1, wherein the step of detecting said generated ions includes capturing said separated ions, wherein the step of capturing said separated ions includes electrostatically collecting said separated ions onto a conducting surface that is maintained with a voltage sufficient to electrostatically attract said separated ions.

33. The method of claim 1, wherein the step of detecting said separated ions is carried out with an ion detector, wherein said ion detector is selected from the group consisting of a condensation particle counter, an electrical current sensor and a mass spectrometer, wherein the step of detecting said separated ions produces data, the method further comprising processing said data mathematically to produce processed data;

and converting said processed data into a form that is recognized by experts in the field of ion mobility spectrometry.

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36. An apparatus, comprising:

means for modifying a sample material by exposing said sample material to physical stress to produce a modified material;

means for generating ions from said modified material to produce generated ions;

means for separating said generated ions to produce separated ions; and

means for detecting said separated ions.

37. The apparatus of claim 36, wherein said means for modifying a sample comprises means for exposing said sample material to at least one of heat, cold, light or a chemical reagent.

40. The apparatus of claim 36, wherein said means for modifying a sample material constantly exposes said sample material to said physical stress by a steadily-changing process.

42. The apparatus of claim 36, wherein said sample material is in the liquid phase, wherein said means for modifying said sample material includes means for pumping said sample material through a capillary, wherein said means for pumping said sample material through a capillary comprises:

a chamber;

means for locating said sample material in said chamber, wherein an end of said capillary is located in said sample material; and

means for providing pressure and heat to said chamber, wherein said sample material is heated to produce said modified material and wherein said pressure forces a portion of said modified material to flow through said capillary and out of said chamber.

53. The apparatus of claim 36, wherein said means for generating ions comprises an electrospray generator configured to produce said generated ions.

54. The apparatus of claim 53, further comprising a mass flow controller that is accurate to +/−

2% of the full-scale flowrate so that accurate quantitation of the electro-sprayed ion concentration can be obtained, wherein stable delivery of gases is provided to said electrospray generator by using said mass flow controller.

55. The apparatus of claim 54, further comprising a camera operatively located for producing images of the ion generating process.

56. The apparatus of claim 55, further comprising means for processing said images with image recognition software, along with a sensor to monitor the electrospray current, as a means to provide feedback to the electrospray process for the purpose of improving the stability of the electrospray process.

57. The apparatus of claim 36, further comprising means for modifying said generated ions prior to separating said ions.

66. The apparatus of claim 36, wherein said means for detecting said generated ions includes means for capturing said separated ions.

67. The apparatus of claim 66, wherein said means for capturing said separated ions includes means for electrostatically collecting said separated ions onto a conducting surface that is maintained with a voltage sufficient to electrostatically attract said separated ions.

68. The apparatus of claim 36, wherein said ion detector is selected from the group consisting of a condensation particle counter, an electrical current sensor and a mass spectrometer, wherein said means for detecting said separated ions is carried out with an ion detector.

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