NANOPORE SEQUENCERS
First Claim
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1. A nanopore sequencer, comprising:
- a cis well;
a trans well;
a nanopore fluidically connecting the cis well and the trans well; and
a modified electrolyte in the cis well, or the trans well, or the cis and trans wells, the modified electrolyte including an electrolyte and a cation complexing agent.
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Abstract
Example nanopore sequencers include a cis well, a trans well, and a nanopore fluidically connecting the cis and trans wells. In one example sequencer, a modified electrolyte (including an electrolyte and a cation complexing agent) is present in the cis well, or the trans well, or in the cis and the trans wells. In another example sequencer, a gel state polyelectrolyte is present in the cis well, or the trans well, or in the cis and the trans wells.
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Citations
20 Claims
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1. A nanopore sequencer, comprising:
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a cis well; a trans well; a nanopore fluidically connecting the cis well and the trans well; and a modified electrolyte in the cis well, or the trans well, or the cis and trans wells, the modified electrolyte including an electrolyte and a cation complexing agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A nanopore sequencer, comprising:
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a cis well; a trans well; a nanopore fluidically connecting the cis well and the trans well; and a polyelectrolyte in a gel state in the cis well, or the trans well, or the cis and trans wells. - View Dependent Claims (11, 12, 13, 14, 15)
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16. A nanopore sequencer, comprising:
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a cis well; a trans well; a nanopore fluidically connecting the cis well and the trans well; a cis well electrode structure associated with the cis well, the cis well electrode structure including a first base electrode and a redox solid immobilized to the first base electrode; a trans well electrode structure associated with the trans well, the trans well electrode structure including a second base electrode and the redox solid immobilized to the second base electrode; and an electrolyte including a cation to be consumed or released in response to respective redox reactions at the cis well electrode structure and the trans well electrode structure. - View Dependent Claims (17, 18, 19, 20)
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Specification