Spectral-Potentiometric-Thermometric Multi-Dimensional Titration Analysis Instrument and Use Method Thereof

• US 20200132704A1
• Filed: 12/23/2019
• Published: 04/30/2020
• Est. Priority Date: 07/15/2019
• Status: Active Grant

• Current Assignee: Fei Wang, Qinhuangdao YUE PENG Technology Company Limited
• Original Assignee: Qinhuangdao YUE PENG Technology Company Limited
• Inventors: WANG, Fei
• Granted Patent: US 11,353,470 B2
• Time in Patent Office: Days
• CPC Class Codes: G01N 2035/00346 Heating or cooling arrangements
• CPC Class Codes: G01N 2035/00534 Mixing by a special element, e.g. stirrer
• CPC Class Codes: G01N 2035/00564 Handling or washing solid phase elements, e.g. beads
• CPC Class Codes: G01N 31/16 using titration
• CPC Class Codes: G01N 31/164 by electrical or electrochemical means
• CPC Class Codes: G01N 35/00584 Control arrangements for automatic analysers

Abstract

The present invention discloses a spectral-potentiometric-thermometric multi-dimensional titration analysis instrument, which comprises a spectral titration measurement device, a thermometric titration measurement device and a potentiometric titration measurement device which are arranged in parallel, meets the simultaneous measurement requirements of different analysis methods in chemical analysis, improves the measurement precision of different measurement methods, and effectively reduces the workload of separate experiments. The present invention further provides a usage method of the analysis instrument, provides analysis results of different angles and different characterization parameters for the change process of the material structure in the chemical reaction by conducting comparison analysis on data obtained using different measurement techniques, and effectively reduces the workload of titration analysis.

Claims

1. A spectral-potentiometric-thermometric multi-dimensional titration analysis instrument, comprising a reagent control system, a titration measurement system and a data processing system, the reagent control system being connected with the data processing system by the titration measurement system, wherein

the reagent control system comprises a reagent compartment and a measurement compartment, the reagent compartment being in communication with the measurement compartment by a reagent pipeline;

the titration measurement system comprises a spectral titration measurement device, a thermometric titration measurement device and a potentiometric titration measurement device, the spectral titration measurement device, the thermometric titration measurement device and the potentiometric titration measurement device being arranged in parallel inside the measurement compartment; and

the data processing system comprises a measurement signal conversion and calculation device, the measurement signal conversion and calculation device being connected with the spectral titration measurement device, the thermometric titration measurement device and the potentiometric titration measurement device respectively by signals.

2. The spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 1, wherein the reagent compartment comprises a titration solution storage container, a reagent control device and a first temperature control device, wherein the titration solution storage container is in communication with the reagent control device by a reagent pipeline, and the first temperature control device is connected with the titration solution storage container and the reagent control device respectively;

the reagent control device comprises a protective gas assembly, a gas filtration assembly and a liquid sensing assembly, wherein the protective gas assembly is configured to provide a protective gas environment for a titration reagent in the titration solution storage container, the gas filtration assembly is configured to filter air gas, and the liquid sensing assembly is configured to sense the remaining amount of the titration solution in the titration solution storage container; and

the first temperature control device comprises a heating assembly, a cooling assembly and a temperature sensing assembly, and the first temperature control device provides a constant-temperature environment for the titration reagent.

3. The spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 2, wherein the measurement compartment comprises a manipulator, a titration head, a titration control device, a reaction container, a stirring device, a cleaning device, a second temperature control device, a gas protection device and a feedback signal device,

wherein the titration head is connected with the measurement compartment wall by the manipulator, to achieve the relative displacement of the titration head and the reaction container;

the titration control device, the stirring device, the cleaning device and the gas protection device are connected with the titration head respectively, and achieve relative displacement to the reaction container through the titration head;

the feedback signal device is connected with the manipulator, the titration control device, the stirring device, the cleaning device, the second temperature control device and the gas protection device respectively by signals, the second temperature control device is configured to control the container temperature of titration reaction, and the gas protection device is configured to provide a protective gas environment for titration reaction; and

the titration control device is in communication with the reagent control device by a pipeline, and the feedback signal device is connected with the measurement signal conversion and calculation device by signals.

4. The spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 3, wherein the thermometric titration measurement device comprises a temperature signal sensor, the potentiometric titration measurement device comprises a potential signal sensor, and the spectral titration measurement device comprises an optical signal sensor, wherein the temperature signal sensor, the potential signal sensor and the optical signal sensor are connected with the reaction container by signals;

the temperature signal sensor and the potential signal sensor are connected with the titration head, and achieve relative displacement to the reaction container through the titration head; and

the spectral titration measurement device further comprises a light source and an optical signal loading component, the light source, the optical signal loading component and the optical signal sensor being connected in sequence by optical signals.

5. The spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 4, wherein the optical signal loading component comprises an optical lens, the optical lens being arranged on the outer wall of the reaction container;

6. The spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 5, wherein the optical signal loading component further comprises a reflector, the reflector being arranged on the outer wall or inside of the reaction container.

7. The spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 1, wherein the spectral-potentiometric-thermometric multi-dimensional titration analysis instrument for chemical reaction further comprises a data output display system, the data output display system being connected with the data processing system to synchronously output and display multi-dimensional titration parameters.

8. A usage method of the spectral-potentiometric-thermometric multi-dimensional titration analysis instrument of claim 1, comprising the following steps:

S1. starting the instrument;

S2. setting environment parameters of the reagent compartment, controlling the temperature of the reagent compartment by the first temperature control device, filtering the air gas by the gas filtration assembly of the reagent control device, and providing a protective gas environment for the titration reagent by the protective gas assembly of the reagent control device;

S3. setting environment parameters of the measurement compartment, setting a titration parameter of the titration reagent by the titration control device, controlling the temperature of the measurement compartment by the second temperature control device, and filling protective gas for the reaction container by the gas protection device;

S4. preprocessing before measurement;

conducting reference calibration on the instrument, and preparing titrate in the reaction container for later use;

S5. setting measurement parameters;

setting at least one metering parameter in the data processing system, selecting one or more of a spectral titration mode, a thermometric titration mode and a potentiometric titration mode, and selecting at least one measurement parameter of the titration modes;

S6. measuring reaction to be measured;

adding the titration reagent in the titration solution storage container into the reaction container by the reagent control device and the titration control device, reacting with the titrate obtained in step S4, and synchronously measuring the reaction solution in the reaction container by one or more of the spectral titration measurement device, the thermometric titration measurement device and the potentiometric titration measurement device, to obtain measurement data corresponding to the metering parameter set tin step S5 and the measurement parameter;

S7. storing and analyzing the measurement data obtained in step S6 by the data processing system, and synchronously displaying the measurement data by the data output display system; and

S8. after titration is completed, terminating the operation of the titration control device, the gas protection device, the stirring device and the second temperature control device by the feedback signal device, and starting the cleaning device to clean the stirring device, the optical signal sensor, the temperature signal sensor and the potential signal sensor which are immersed in the reaction solution.

9. The usage method of the spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 8, wherein the measurement mode of the spectral titration mode described in step S5 includes a total transmission mode, a total transmission-total reflection mode, a semi-transmission-semi reflection mode, or a reflective mode.

10. The usage method of the spectral-potentiometric-thermometric multi-dimensional titration analysis instrument according to claim 8, wherein the measurement mode of the thermometric titration mode described in step S5 includes an immersion contact mode, an adherence contact mode, and a solution surface irradiation mode or container surface irradiation mode.