MEDICAL INSTRUMENT FOR IN VIVO HEAT SOURCE

• US 20200135507A1
• Filed: 10/29/2019
• Published: 04/30/2020
• Est. Priority Date: 05/26/2016
• Status: Active Grant

• Current Assignee: Anand Deo
• Original Assignee: Anand Deo
• Inventors: Deo, Anand
• Granted Patent: US 11,712,368 B2
• Time in Patent Office: Days
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: H01L 21/324 Thermal treatment for modifying the properties of semiconductor bodies, e.g. annealing, sintering H01L21/20 - H01L21/288 and H01L21/302 - H01L21/322 take precedence
• CPC Class Codes: H01L 21/67103 mainly by conduction
• CPC Class Codes: H01L 21/67248 Temperature monitoring
• CPC Class Codes: H05B 1/023 Industrial applications
• CPC Class Codes: H05B 6/50 for monitoring or control

Abstract

A biocompatible medical device can be at least partially implantable into a living human or animal subject to provide active treatment of biofilm that can occur use within the subject. The medical device can include a catheter, including an interior conduit capable of permitting fluid flow. A heating device can be located on a portion of the catheter to be located within the subject, the heating device including at least a pair of electrodes having a variable spacing therebetween, the variable spacing specified to allow heat to be generated using a time-varying electromagnetic input signal providing a variable frequency to control a variable location along the electrodes at which heat is generated, such as can provide a virtual matrix of local heat sources.

Claims

1. A medical device that is at least partially insertable or implantable into a living human or animal subject to generate heat in vivo within the subject, the medical device comprising:

a body, sized and shaped to include a biocompatible portion that is configured to be insertable or implantable into the subject, the body including;

an electrical conductor, connected or coupled to receive an AC electromagnetic input signal; and

at least one of a semiconductor, a lossy dielectric, a thin-film metal, or a crystalline active substrate, arranged with respect to the electrical conductor to use the same AC electromagnetic input signal to both (1) select a heat source location in response to the same AC electromagnetic input signal being at a specified frequency and also to (2) generate heat in the active substrate at the selected heat source location selected.

2. The medical device of claim 1, wherein the electrical conductor includes a pair of electrodes having a spacing therebetween, the spacing specified to allow heat to be generated using a time-varying electromagnetic input signal providing a variable frequency to control a variable location along the electrodes at which heat is generated in the active substrate.

3. The medical device of claim 1, comprising a planar resonator including selectable heat source locations at different locations along a shared main line.

4. The medical device of claim 3, wherein the planar resonator includes at least one of:

the electrical conductor configured as a planar resonator line including a specified multiple of half-wavelengths (λ

/2) in the substrate of a desired frequency of an electromagnetic input signal to be used to select the planar resonator in a non-grounded configuration;

or

the electrical conductor configured as a planar resonator line including a specified multiple of quarter-wavelengths (λ

/4) in the substrate of a desired frequency of an electromagnetic input signal to be used to select the planar resonator in a grounded configuration.

5. The medical device of claim 1, comprising a plurality of heat source locations arranged in a strip-line configuration at different locations along a shared main line.

6. The medical device of claim 1, including, at the heat source location, a capacitive coupling between the electrical conductor and the active substrate.

7. The medical device of claim 1, wherein the body includes an interior conduit capable of permitting fluid flow.

8. The medical device of claim 1, comprising a sensor located on the body at or near the heat source location, the sensor providing a sensor reading used to control the selecting and energizing of the heat source location.

9. The medical device of claim 1, comprising a piezoelectric or other mechanical output transducer located on the body.

10. A method of using a biocompatible medical device that is at least partially implantable into a living human or animal subject, the method comprising:

obtaining or providing the medical device including a body including a heat source location that is both selectable and energizable by specifying or varying a frequency of an AC electromagnetic input signal; and

applying the same AC electromagnetic input signal to both select and energize the heat source location, via an electrical conductor connected or coupled to receive the same AC electromagnetic input signal, and using a semiconductor, a lossy dielectric, thin-film metal, or a crystalline active substrate, arranged with respect to the electrical conductor to use the same selecting and energizing AC electromagnetic input signal to generate heat in the active substrate in response to the same AC electromagnetic input signal being at the specified frequency.

11. The method of claim 10, comprising sweeping across heat source locations individually or in groups to selectively energize heat source locations to attain a desired operating temperature at a first location for a desired first duration without exceeding a biological thermal budget at the first location, then selectively energizing ones of the heat source locations to attain a desired operating temperature at a different second location for a desired second duration without exceeding a biological thermal budget at the second location.

12. The method of claim 10, comprising dynamically generating heat in the active substrate in response to the AC electromagnetic input signal applied to the electrical conductor, including using the AC electromagnetic input signal to manage an electrical conduction within the active substrate for the dynamically generating heat in the active substrate.

13. The method of claim 10, comprising providing or using, at the heat source location, a pair of electrodes with variable interelectrode spacing, a planar resonator structure, or a strip-line structure.

14. The method of claim 10, comprising using the heat source location for providing an amount of heat to inhibit, disrupt, or sterilize a biofilm within, on, or adjacent to the body, wherein the providing the amount of heat is less than an amount of heat to damage a biological tissue or fluid adjacent to or near the body.

15. The method of claim 10, comprising using a sensor reading to control at east one of the selecting or energizing of the heat source location.

16. The method of claim 15, further comprising sweeping across heat source locations individually or in groups to selectively energize heat source locations to attain a desired operating temperature based on the sensor reading, wherein the sensor reading includes information about a temperature associated with at least a portion of the body.

17. A method of using a biocompatible medical device that is at least partially implantable into a living human or animal subject, the method comprising:

obtaining or providing the medical device including a body including a heat source location;

applying an electromagnetic input signal to selectively energize the heat source location; and

applying a first polarity voltage, at a location on the body that is configured to be inserted into subject, to attract a oppositely charged pathogen toward the elongate body for concurrent or subsequent heat neutralization by the applying an electromagnetic input signal to selectively energize the heat source location.

18. The method of claim 17;

wherein the obtaining or providing the medical device comprises obtaining or providing a plurality of heat source locations including or corresponding to at least one of;

a pair of electrodes with variable interelectrode spacing;

a planar resonator structure;

or a strip-line structure.

19. The method of claim 17, wherein the applying the first polarity voltage includes applying a DC or slowly varying AC voltage.

20. The method of claim 17, comprising using a sensed temperature for controlling the selective energizing of the heat source location.