Method of preparing 3, 5, 3' l-tri-iodothyronine and pharmaceutical compositions thereof
First Claim
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1. THE METHOD OF MANUFACTURING 3,5,3'"'"''"'"'-L-TRI-IODO-THY-ONINE, RONINE SUBSTANTIALLY FREE FROM D-FORM WHICH COMPRISES THE STEPS OF IODINATING 3,5-L-DI-IODO-THYRONINE IN AN ALKALINE MEDIUM TO FORM 3,5,3-L-TRI-DIODO-THYRONINE CONTAMINATED WITH THYROXINE, ACIDIFYING SAID MISTURE TO BRING THE PH THEREOF TO ABOUT 4 TO FORM A PRECIPITATE, RECOVERING THE PRECIPITATE, REDISSOLVING THE PRECIPITATE IN BOILING HYDROCHLORIC ACID OF APPROXIMATELY 2N CONCENTRATION, FILTERING THE SOLUTION TO REMOVE THEREFROM INSOLUBLE THYROXINE HYDROCHLORIDE, ADJUSTING THE FILTRATE TO THE PH OF ABOUT 4 TO PRECIPITATE THE 3,5,3'"'"''"'"'-L-TRI-IODO-THYRONINE, AND SEPARATING THE PRECIPITATE FROM THE SOLUTION.
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1 Claim
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1. THE METHOD OF MANUFACTURING 3,5,3'"'"''"'"'-L-TRI-IODO-THY-ONINE, RONINE SUBSTANTIALLY FREE FROM D-FORM WHICH COMPRISES THE STEPS OF IODINATING 3,5-L-DI-IODO-THYRONINE IN AN ALKALINE MEDIUM TO FORM 3,5,3-L-TRI-DIODO-THYRONINE CONTAMINATED WITH THYROXINE, ACIDIFYING SAID MISTURE TO BRING THE PH THEREOF TO ABOUT 4 TO FORM A PRECIPITATE, RECOVERING THE PRECIPITATE, REDISSOLVING THE PRECIPITATE IN BOILING HYDROCHLORIC ACID OF APPROXIMATELY 2N CONCENTRATION, FILTERING THE SOLUTION TO REMOVE THEREFROM INSOLUBLE THYROXINE HYDROCHLORIDE, ADJUSTING THE FILTRATE TO THE PH OF ABOUT 4 TO PRECIPITATE THE 3,5,3'"'"''"'"'-L-TRI-IODO-THYRONINE, AND SEPARATING THE PRECIPITATE FROM THE SOLUTION.
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Current AssigneeJack Gross, Rosalind Pitt-Rivers
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Original AssigneeJack Gross, Rosalind Pitt-Rivers
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InventorsROSALIND PITT-RIVERS, Gross, Jack
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Application NumberUS03/338,914Time in Patent Office1,812 DaysField of SearchUS Class Current514/567CPC Class CodesC07C 227/16 by reactions not involving ...
