Injectable insulin preparations with protracted effect and process of producing same
First Claim
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1. AN INJECTABLE INSULIN PREPARATION WITH PROTRACTED EFFECT, COMPRISING A STERILE SUSPENSION OF AMORPHOUS ZINC PROTAMINE INSULIN IN AN AQUEOUS SUSPENSION MEDIUM HAVING A PH-VALUE BETWEEN 6 AND 8, SAID SUSPENSION CONTAINING PROTAMINE IN AN AMOUNT OF AT LEAST ONE MG. PER 1000 INTERNATIONAL UNITS OF INSULIN BUT NOT EXCEEDING THE AMOUNT NECESSARY FOR SUBSTANTIALLY COMPLETE PRECIPITATION OF THE INSULIN, AND ZINC IN AN AMOUNT BETWEEN 1/4 AND 20 MGS. PER 1000 INTERNATIONAL UNITS OF INSULIN, SAID SUSPENSION BEING ALSO FREE FROM PHOSPHATE AND CITRATE IONS IN AMOUNTS PREVENTING THE SUPPRESSION BY THE ZINC OF THE SOLUBILITY OF THE INSULIN AT PH 7.
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1 Claim
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1. AN INJECTABLE INSULIN PREPARATION WITH PROTRACTED EFFECT, COMPRISING A STERILE SUSPENSION OF AMORPHOUS ZINC PROTAMINE INSULIN IN AN AQUEOUS SUSPENSION MEDIUM HAVING A PH-VALUE BETWEEN 6 AND 8, SAID SUSPENSION CONTAINING PROTAMINE IN AN AMOUNT OF AT LEAST ONE MG. PER 1000 INTERNATIONAL UNITS OF INSULIN BUT NOT EXCEEDING THE AMOUNT NECESSARY FOR SUBSTANTIALLY COMPLETE PRECIPITATION OF THE INSULIN, AND ZINC IN AN AMOUNT BETWEEN 1/4 AND 20 MGS. PER 1000 INTERNATIONAL UNITS OF INSULIN, SAID SUSPENSION BEING ALSO FREE FROM PHOSPHATE AND CITRATE IONS IN AMOUNTS PREVENTING THE SUPPRESSION BY THE ZINC OF THE SOLUBILITY OF THE INSULIN AT PH 7.
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Current AssigneeJorgen Schlichtkrull, Karl Petersen
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Original AssigneeJorgen Schlichtkrull, Karl Petersen
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InventorsPetersen, Karl, JORGEN SCHLICHTKRULL
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Application NumberUS03/433,271Time in Patent Office1,551 DaysField of SearchUS Class Current514/6.6CPC Class CodesA61K 38/28 Insulins
