Process for the production of 20-keto-21-iodo steroids

• US 2,874,154 A
• Filed: 10/11/1955
• Issued: 02/17/1959
• Est. Priority Date: 10/15/1954
• Status: Expired due to Term

• Current Assignee: George Rosenkranz, Gilbert Stork, Howard J. Ringold
• Original Assignee: George Rosenkranz, Gilbert Stork, Howard J. Ringold
• Inventors: Stork, Gilbert, Ringold, Howard J., Rosenkranz, George
• Application Number:
  US03/539,918
• Time in Patent Office: 1,225 Days
• US Class Current: 540/84
• CPC Class Codes: C07J 5/00 Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
• CPC Class Codes: C07J 75/00 Processes for the preparation of steroids in general

Claims

1. A PROCESS FOR THE PRODUCTION OF STEROIDAL 20-KETO 21-IODO COMPOUNDS SELECTED FROM THE GROUP CONSISTING OF PREGNENTS AND 19-NORPREGNENES COMPRISING REACTING THE CORRESPONDING 21-UNSUBSTITUTED STERIOD WITH IODINE IN THE PRESENCE OF AN INERT ORGANIC NON-KETONIC SOLVENT INCLUDING INORGANIC ALKALI.