Insulin crystal preparations and methods of producing them
First Claim
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1. AN INSULIN CRYSTAL HAVING BOUND WITH THE INSULIN TO FORM PART OF THE INSULIN MOLECULE AT LEAST ONE METAL SELECTED FROM THE GROUP CONSISTING OF ZINC, COBALT, NICKEL CADMIUM, COPPER, MANGANESE AND IRON, IN AN AMOUNT OF AT LEAST ABOUT 0.35 MILIEQUAVALENT PER GRAM, SAID INSULIN CRYSTAL BEING SUBSTANTIALLY INSOLUBLE IN WATER AT PH 7 AND EXHIBITING A PROLONGED BLOOD-SUGAR LOWERING ACTION WHEN SUSPENDED IN WATER AND INJECTED PARENTERALLY.
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1 Claim
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1. AN INSULIN CRYSTAL HAVING BOUND WITH THE INSULIN TO FORM PART OF THE INSULIN MOLECULE AT LEAST ONE METAL SELECTED FROM THE GROUP CONSISTING OF ZINC, COBALT, NICKEL CADMIUM, COPPER, MANGANESE AND IRON, IN AN AMOUNT OF AT LEAST ABOUT 0.35 MILIEQUAVALENT PER GRAM, SAID INSULIN CRYSTAL BEING SUBSTANTIALLY INSOLUBLE IN WATER AT PH 7 AND EXHIBITING A PROLONGED BLOOD-SUGAR LOWERING ACTION WHEN SUSPENDED IN WATER AND INJECTED PARENTERALLY.
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Current AssigneeJorgen Schlichtkrull, Karl Petersen, Knud Hallas-Moller
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Original AssigneeJorgen Schlichtkrull, Karl Petersen, Knud Hallas-Moller
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InventorsPetersen, Karl, JORGEN SCHLICHTKRULL, KNUD HALLAS-MOLLER
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Application NumberUS03/219,127Time in Patent Office2,933 DaysField of SearchUS Class Current514/6.4CPC Class CodesA61K 38/28 Insulins
