Injectable insulin preparation with protracted effect
First Claim
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1. AN INJECTABLE INSULIN PREPARATION HAVING A PROTRACTED EFFECT CONSISTING ESSENTIALLY OF A STERILE-AQUEOUS SUSPENSION OF AMORPHOUS INSULIN OBTAINED BY PRECIPITATION OF DISSOLVED ZINE INSULIN, SAID SUSPENSION HAVING A PH VALUE OF 6.5 TO 8.5 AND HAVING A ZINC CONTENT OF 1 TO 6 GAMMA PER INSULIN UNIT, AND SAID SUSPENSION BEING SUBSTANTIALLY FREE FROM BUFFER IONS WHICH HAVE A GREATER AFFINITY FOR THE ZINC IONS THAN DOES INSULIN AN THEREBY BIND THE ZINC AT PH 7, LESS THAN 2% OF THE INSULIN PRESENT IN THE SUSPENSION BEING IN DISSOLVED STATE.
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1 Claim
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1. AN INJECTABLE INSULIN PREPARATION HAVING A PROTRACTED EFFECT CONSISTING ESSENTIALLY OF A STERILE-AQUEOUS SUSPENSION OF AMORPHOUS INSULIN OBTAINED BY PRECIPITATION OF DISSOLVED ZINE INSULIN, SAID SUSPENSION HAVING A PH VALUE OF 6.5 TO 8.5 AND HAVING A ZINC CONTENT OF 1 TO 6 GAMMA PER INSULIN UNIT, AND SAID SUSPENSION BEING SUBSTANTIALLY FREE FROM BUFFER IONS WHICH HAVE A GREATER AFFINITY FOR THE ZINC IONS THAN DOES INSULIN AN THEREBY BIND THE ZINC AT PH 7, LESS THAN 2% OF THE INSULIN PRESENT IN THE SUSPENSION BEING IN DISSOLVED STATE.
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Current AssigneeJorgen Schlichtkrull, Karl Petersen, Knud Hallas-Moller
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Original AssigneeJorgen Schlichtkrull, Karl Petersen, Knud Hallas-Moller
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InventorsPetersen, Karl, JORGEN SCHLICHTKRULL, KNUD HALLAS-MOLLER
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Application NumberUS03/295,337Time in Patent Office2,485 DaysField of SearchUS Class Current514/6.4CPC Class CodesA61K 38/28 Insulins
