Process for producing thyroxine
First Claim
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1. A PROCESS FOR THE PRODUCTION OF THYROXINE COMPRISING THE STEPS OF INCUBATION AN ALKYHL ESTER OF N-ACYLDIIODOTYROSINE DERIVED FROM ONE OF THE LOWER ALKANOLS AND ONE OF THE LOWER ALKANOIC ACIDS IN AN AQUEOUS SOLUTION CONTAINING UP TO ABOUT 70% OF ETHANOL AND HAVING A PH IN THE RANBE OF 9.5 TO 10.5 IN THE PRESENCE OF BETWEEN ABOUT 1.5% AND 5.0% BY WEIGHT OF A MANGANESE-CONTAINING CATALYST WHILE PASSING SUBSTANTIALLY THE TEMPERATHROUGH THE SOLUTION AND WHILE MAINTAINING THE TEMPERATURE IN THE RANGE 25-78%C., AND HYDROLYTICALLY REMOVING THE ACYL AND ESTER SUBTITUENTS FROM THE ESTER OF N-ACYLTHYROZINE OBTAINED IN THE SAID INCUBATION STEP.
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1 Claim
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1. A PROCESS FOR THE PRODUCTION OF THYROXINE COMPRISING THE STEPS OF INCUBATION AN ALKYHL ESTER OF N-ACYLDIIODOTYROSINE DERIVED FROM ONE OF THE LOWER ALKANOLS AND ONE OF THE LOWER ALKANOIC ACIDS IN AN AQUEOUS SOLUTION CONTAINING UP TO ABOUT 70% OF ETHANOL AND HAVING A PH IN THE RANBE OF 9.5 TO 10.5 IN THE PRESENCE OF BETWEEN ABOUT 1.5% AND 5.0% BY WEIGHT OF A MANGANESE-CONTAINING CATALYST WHILE PASSING SUBSTANTIALLY THE TEMPERATHROUGH THE SOLUTION AND WHILE MAINTAINING THE TEMPERATURE IN THE RANGE 25-78%C., AND HYDROLYTICALLY REMOVING THE ACYL AND ESTER SUBTITUENTS FROM THE ESTER OF N-ACYLTHYROZINE OBTAINED IN THE SAID INCUBATION STEP.
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Current AssigneeLeonard G. Ginger, Paul Z. Anthony
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Original AssigneeLeonard G. Ginger, Paul Z. Anthony
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InventorsGinger, Leonard G., Anthony, Paul Z.
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Application NumberUS03/552,015Time in Patent Office1,271 DaysField of SearchUS Class Current562/447CPC Class CodesC07C 227/16 by reactions not involving ...C07C 229/36 with at least one amino gro...C07C 319/20 by reactions not involving ...
