Process for producing thyroxine

• US 2,889,364 A
• Filed: 05/03/1957
• Issued: 06/02/1959
• Est. Priority Date: 05/03/1957
• Status: Expired due to Term

• Current Assignee: Leonard G. Ginger, Paul Z. Anthony
• Original Assignee: Leonard G. Ginger, Paul Z. Anthony
• Inventors: Anthony, Paul Z., Ginger, Leonard G.
• Application Number:
  US03/656,982
• Time in Patent Office: 760 Days
• US Class Current: 562/447
• CPC Class Codes: C07C 227/16 by reactions not involving the amino or carboxyl groups
• CPC Class Codes: C07C 319/20 by reactions not involving the formation of sulfide groups
• CPC Class Codes: C07C 323/58 with amino groups bound to the carbon skeleton

Claims

1. A PROCESS FOR THE PRODUCTION OF THYROXINE COMPRISING THE STEPS OF INCUBATING AN AMIDE OF N-ACYLDIIODOTYROSINE IN AN AQUEOUS SOLUTION CONTAINING ABOUT 50% ETHANOL AND HAVING A PH OF ABOUT 10.5 IN THE PRESENCE OF ABOUT 15% BY WEIGHT OF A MANGANESE-CONTAINING CATALYST WHILE PASSING SUBSTANTIALLY PURE OXYGEN THROUGH THE SOLUTION AND WHILE MAINTAINING A TEMPERATURE ABOUT 44*C., THE AMIDO NITROGEN SUBSTITUENTS OF SAID AMIDE BEING MEMBERS SELECTED FROM THE CLASS CONSISTING OF HYDROGEN AND THE LOWER ALKANES, AND THE ACYL PORTION OF SAID N-ACYLDIIODOTYROSINE BEING DERIVED FROM ONE OF THE LOWER ALKANOIC ACIDS, AND HYDROLYTICALLY CLEAVING BOTH THE AMIDE PORTION AND THE SAID ACYL PORTION FROM THE N-ACYLTHYROXINAMIDE DERIVATIVE OBTAINED IN SAID INCUBATION STEP.