Drug composition

• US 2,987,445 A
• Filed: 10/10/1958
• Issued: 06/06/1961
• Est. Priority Date: 10/10/1958
• Status: Expired due to Term

• Current Assignee: Charles L. Levesque
• Original Assignee: Charles L. Levesque
• Inventors: Levesque, Charles L.
• Application Number:
  US03/766,496
• Time in Patent Office: 970 Days
• US Class Current: 424/469
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: Y10S 424/07 Microporous membranes

Claims

1. A COMPOSITION IN ORAL DOSAGE FORM WHICH COMPRISES (A) A POROUS PLASTIC MATRIX WHICH IS SUBSTANTIALLY INERT TO GASTRO-INTESTINAL FLUIDS, SAID PLASTIC BEING PERMEABLE TO THE WATER COMPONENT OF GASTRO-INTESTINAL FLUIDS TO AT LEAST A SMALL EXTENT AND BEING SELECTED FROM THE GROUP CONSISTING OF CRYSTALLINE POLYMERS HAVING A MELTING POINT OF AT LEAST ABOUT 105*F. AND AMORPHOUS POLYMERS HAVING A GLASS POINT OF AT LEAST ABOUT 105*F. AND (B) AN AMOUNT OF A WATER SOLUBLE DRUG SUFFICIENT TO GIVE A PHARMACOLOGIC RESPONSE UPON INGESTION AND ABSORPTION, SAID DRUG BEING UNIFORMLY DISPERSED WITHIN THE PORES OF SAID PLASTIC MATRIX AND SAID COMPOSITION ADAPTED TO RELEASE AN EFFECTIVE AMOUNT OF THE DRUG GRADUALLY OVER A PERIOD OF TIME DURING WHICH THE DOSAGE FORM IS PRESENT IN THE BODY.