Stable therapeutic compositions containing acetylsalicylic acid-anhydride

• US 2,990,328 A
• Filed: 04/18/1958
• Issued: 06/27/1961
• Est. Priority Date: 04/18/1958
• Status: Expired due to Term

• Current Assignee: Edward H. Lincoln
• Original Assignee: Edward H. Lincoln
• Inventors: Lincoln, Edward H.
• Application Number:
  US03/729,258
• Time in Patent Office: 1,166 Days
• US Class Current: 514/163
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/621 having the hydroxy group in position 2 esterified, e.g. benorylate
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/183 Amino acids, e.g. glycine, EDTA or aspartame

Claims

1. A STABLE, SOLID ORAL THERAPEUTIC PREPARATION IN DOSAGE UNIT FORM COMPRISING (ACETYLSALICYLIC ACID)-ANHYDRIDE AND A PHARMACEUTICALLY ACCEPTABLE NON-ALKALINE DILUENT CONTAINING FROM ABOUT 0.3 TO ABOUT 17% BY WEIGHT OF SAID ANYHDRIDE OF A PHARMACEUTICALLY-ACCEPTABLE ACID-REACTING STABILIZING COMPOUND TO STABILIZE THE PREPARATION AGAINST DECOMPOSITION BY ALKALI, WHICH DILUENT DOES NOT LOWER SUBSTANTIALLY THE MELTING POINT OF SAID ANHYDRIDE.