Preparation of triiodothyronine

• US 2,993,928 A
• Filed: 01/14/1958
• Issued: 07/25/1961
• Est. Priority Date: 01/15/1957
• Status: Expired due to Term

• Current Assignee: Aubrey Wetherill Lewis, Kumar Razdan Raj
• Original Assignee: Aubrey Wetherill Lewis, Kumar Razdan Raj
• Inventors: KUMAR RAZDAN RAJ, AUBREY WETHERILL LEWIS
• Application Number:
  US03/708,749
• Time in Patent Office: 1,288 Days
• US Class Current: 562/447
• CPC Class Codes: C07C 227/16 by reactions not involving the amino or carboxyl groups
• CPC Class Codes: C07C 229/36 with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Claims

1. A PROCESS FOR THE PURIFICATION OF CRUDE TRIIODOTHYRONINE CONTAINING CONTAMINATING AMOUNMTS OF AT LEAST ONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF DIIODOTHYRONINE AND THYROXINE, SAID TRIIODOTHYRONINE BEING OBTAINED BY IDODINATING DIIODOTHYRONINE IN AN AQUEOUS MEDIUM CONTAINING ALKALI METAL IONS AND A BAIS COMPOUND SELECTED FROM A GROUP CONSISTING OF AMMONIA, A PRIMARY AMINE HAVING A PKH GREATER THAN 7.2, WHEREBY SECONDARY AMINE HVING A PKH GRETER THAN 7.2, WHEREBY A COMPLEX IS FORMED IN SITU BY REACTION OF TRIIODOTHYRONINE AS IT IS FORMED WITH SAID IONS AND SAID BASIC COMPOUND, WHICH PROCESS COMPRISES MAINTAINING SAID AQUEOUS MEDIUM AT A TEMPERATURE OF 15-35*C. TO KEEP SAID COMPLEX AND SAID CONTAMINATING COMPOUND IN SOLUTION AND SUBSEQUENTLY COOLING SAID AQUEOUS MEDIUM TO PRECIPITATE SAID COMPLEX WITHOUT PRECIPITATING SAID CONTAMINATING COMPOUND.