Compositions and method for the parenteral administration of thyroxine

• US 3,035,974 A
• Filed: 02/18/1960
• Issued: 05/22/1962
• Est. Priority Date: 02/18/1960
• Status: Expired due to Term

• Current Assignee: Murray Israel
• Original Assignee: Murray Israel
• Inventors: MURRAY ISRAEL
• Application Number:
  US04/009,438
• Time in Patent Office: 824 Days
• US Class Current: 514/52
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00

Claims

1. AN INJECTABLE PHARMACCEUTICAL COMPOSITION FOR THE PARENTERAL THERAPEUTIC USE OF THYROXINE, SAID COMPOSITION BEING THERAPEUTICALLY ACCEPTACLE FOR SUCH THERAPY AT A PROTRACTED DOSAGE REGIMEN UBDER WHICH ITS THYROXINE CONTENT WOULD PROVOKE TOXIC MANIFESTATIONS IF ADMINISTERED ALONE, CONSISTING ESSENTIALLY OF AN AQUEOUS MEDIUM CONTAINING NOT LESS THAN ABOUT 0.06 MG/ML OF A WATER-SOLUBLE SALT OF THYROXINE, AND ALSO VITAMIN B12 AND GELATIN, THE GELATIN BEING PRESENT IN AN AMOUNT GREATER THAN THE B12 AND THE B12 AND GELATIN TOGETHER HAVING AT LEAST ABOUT FIVE TIMES THE WEIGHT OF THE THYROXINE, THE B12 AND GELATIN BEING ASSOCIATED WITH EACH OTHER IN THE FORM OF A MACROANIONIC SUBSTANCE IN DISPERSED PHASE AND HAVING A MOLECULAR WEIGHT OF AT LEAST ABOUT 100,000.