Sustained release tablet

• US 3,065,143 A
• Filed: 04/19/1960
• Issued: 11/20/1962
• Est. Priority Date: 04/19/1960
• Status: Expired due to Term

• Current Assignee: George L. Christenson, Lamar B. Dale
• Original Assignee: George L. Christenson, Lamar B. Dale
• Inventors: Christenson, George L., Dale, Lamar B.
• Application Number:
  US04/023,240
• Time in Patent Office: 945 Days
• US Class Current: 424/468
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Claims

1. A COMPRESSED TABLET FOR ORAL ADMINISTRATION WHICH IS CHARACTERIZED BY ITS ABILITY TO RESIST SPONTANEOUS DISINTEGRATION AND TO RELEASE MEDICAMENT AT A SUBSTANTIALLY UNIFORM RATE OVER A PERIOD OF AT LEAST FOUR HOURS IN THE GASTRO-INTESTINAL TRACT WHICH TABLET CONSISTS ESSENTIALLY OF A COMPRESSED MIXTURE OF AN EFFECTIVE AMOUNT OF A MEDICAMENT AND AT LEAST ONE-THIRD PART BY WEIGHT OF THE WEIGHT OF THE TABLET OF A PHARMACEUTICALLY ACCEPTABLE HYDROPHILIC GUM WHICH RAPIDLY ABSORBS WATER AND SWELLS AT 37*C. TO FORM A SOFT MUCILAGINOUS GEL BARRIER ON THE SURFACE OF THE TABLET WHEN BROUGHT INTO CONTACT WITH THE AQUEOUS FLUIDS OF THE GASTRO-INTESTINAL TRACT WHICH PREVENTS RAPID DISINTEGRATION OF THE TABLET AND RELEASE OF THE MEDICAMENT CONTAINED THEREIN WHEN TAKEN ORALLY, BUT ALLOWS SLOW DISINTEGRATION OF THE TABLET AND RELEASE OF MEDICAMENT OVER A PERIOD OF AT LEAST FOUR HOURS.