Pharmaceutical preparations and method and apparatus for making same
First Claim
1. THE METHOD OF TREATING A VERTEBRATE TYPE ANIMAL WHICH COMPRISES ADMINISTERING ORALLY A PLURALITY OF DROPLET SIZE SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS COMPRISING A CONGEALABLE SOL AND A PHARMACOLOGICALLY ACTIVE INGREDIENT SUFFICIENT TO GIVE A PHARMACOLOGICAL RESPONSE UPON INGESTION AND ABSORPTION, SAID INGREDIENT BEING UNIFORMLY DISTRIBUTED THROUGHOUT SAID SOL, SAID DROPLET BEADS BEING MADE BY THE STEPS OF DIRECTING AN IMMISCIBLE LIQUID IN SUCH A MANNER AS TO FORM A CONTINUOUS STREAM, DIRECTING A CONGEALABLE SOL HAVING SAID PHARMACOLIGICALLY ACTIVE INGREDIENT DISTRIBUTED UNIFORMLY THERETHROUGH THROUGH A FINE ORIFICE OF A DIAMETER NOT GREATER THAN THE INTERNAL DIAMEETER OF A SIZE 18 HYPODERMIC NEEDLE UNDER PRESSURE SUFFICIENT TO FORM A FINE UNINTERRUPTED FILAMENT, DIRECTING THE UNINTERRUPTED FILAMENT INTO THE STREAM, MAINTAINING THE TEMPERATURE OF SAID STREAM OF IMMISCIBLE LIQUID BELOW THE CONGEALING TEMPERATURE OF SAID CONGEALABLE SOL, CONTROLLING THE VELOCITIES OF THE STREAM RELATIVE TO THE FILAMENT AS THEY MOVE ALONG IN THE PATH OF THE STREAM IN SUCH A MANNER AS TO CAUSE THE UNINTERRUPTED FILAMENT TO MOVE UNINTERRUPTEDLY IN THE DIRECTION OF MOVEMENT OF THE STREAM ALONG THE STREAM AT A VELOCITY SUFFICIENT TO PREVENT SUBSTANTIAL INCREASE IN GROSS SECTION OF THE UNITERRUPTED FILAMENT AND THEREAFTER TO CAUSE THE FILAMENT TO BREAK UP INTO ELONGATED SEGMENTS WHICH QUICKLY CONTRACT LENGTHWISE INTO SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS AND THUS PROVIDE SPACES BETWEEN THE INDIVIDUAL BEADS TO PREVENT COALESCING AS THE BEADS FLOW IN THE IMMISCIBLE STREAM AND THEREAFTER GEL.
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Accused Products
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Citations
1 Claim
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1. THE METHOD OF TREATING A VERTEBRATE TYPE ANIMAL WHICH COMPRISES ADMINISTERING ORALLY A PLURALITY OF DROPLET SIZE SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS COMPRISING A CONGEALABLE SOL AND A PHARMACOLOGICALLY ACTIVE INGREDIENT SUFFICIENT TO GIVE A PHARMACOLOGICAL RESPONSE UPON INGESTION AND ABSORPTION, SAID INGREDIENT BEING UNIFORMLY DISTRIBUTED THROUGHOUT SAID SOL, SAID DROPLET BEADS BEING MADE BY THE STEPS OF DIRECTING AN IMMISCIBLE LIQUID IN SUCH A MANNER AS TO FORM A CONTINUOUS STREAM, DIRECTING A CONGEALABLE SOL HAVING SAID PHARMACOLIGICALLY ACTIVE INGREDIENT DISTRIBUTED UNIFORMLY THERETHROUGH THROUGH A FINE ORIFICE OF A DIAMETER NOT GREATER THAN THE INTERNAL DIAMEETER OF A SIZE 18 HYPODERMIC NEEDLE UNDER PRESSURE SUFFICIENT TO FORM A FINE UNINTERRUPTED FILAMENT, DIRECTING THE UNINTERRUPTED FILAMENT INTO THE STREAM, MAINTAINING THE TEMPERATURE OF SAID STREAM OF IMMISCIBLE LIQUID BELOW THE CONGEALING TEMPERATURE OF SAID CONGEALABLE SOL, CONTROLLING THE VELOCITIES OF THE STREAM RELATIVE TO THE FILAMENT AS THEY MOVE ALONG IN THE PATH OF THE STREAM IN SUCH A MANNER AS TO CAUSE THE UNINTERRUPTED FILAMENT TO MOVE UNINTERRUPTEDLY IN THE DIRECTION OF MOVEMENT OF THE STREAM ALONG THE STREAM AT A VELOCITY SUFFICIENT TO PREVENT SUBSTANTIAL INCREASE IN GROSS SECTION OF THE UNITERRUPTED FILAMENT AND THEREAFTER TO CAUSE THE FILAMENT TO BREAK UP INTO ELONGATED SEGMENTS WHICH QUICKLY CONTRACT LENGTHWISE INTO SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS AND THUS PROVIDE SPACES BETWEEN THE INDIVIDUAL BEADS TO PREVENT COALESCING AS THE BEADS FLOW IN THE IMMISCIBLE STREAM AND THEREAFTER GEL.
Specification
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Current AssigneeCarl E. Fisher Jr, Charles H. Wilson
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Original AssigneeCarl E. Fisher Jr, Charles H. Wilson
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InventorsFisher, Carl E. Jr., Wilson, Charles H.
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Application NumberUS04/021,524Time in Patent Office1,149 DaysField of SearchUS Class Current424/489CPC Class CodesA61J 3/06 into the form of pills, loz...A61K 9/1658 Proteins, e.g. albumin, gel...B01J 13/08 Simple coacervation, i.e. a...Y10T 428/2984 Microcapsule with fluid cor...Y10T 428/2989 Microcapsule with solid cor...
