8-(1,4-BENZODIOXAN-2-YLMETHYL)-3-OXO-1-THIA-4,8-DIAZASPIRO(4,5)DECANES

• US 3,577,425 A
• Filed: 12/10/1968
• Issued: 05/04/1971
• Est. Priority Date: 12/11/1967
• Status: Expired due to Term

• Current Assignee: Arimura Katsuo, Imamura Hiroshi, Kobayakawa Toshihiro, Nakanishi Michio
• Original Assignee: Arimura Katsuo, Imamura Hiroshi, Kobayakawa Toshihiro, Nakanishi Michio
• Inventors: NAKANISHI MICHIO, ARIMURA KATSUO, IMAMURA HIROSHI, KOBAYAKAWA TOSHIHIRO
• Application Number:
  US04/782,752
• Time in Patent Office: 875 Days
• US Class Current: 546/19
• CPC Class Codes: C07D 513/10 Spiro-condensed systems

Abstract

BENZODIOXANE DERIVATIVES OF THE FORMULA

2-((4-(A2-Z-),4-(R2-N(-C=O)-)-PIPERIDIN-1-YL-)-A1-),R1-

1,4-BENZODIOXAN

AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, WHEREIN R1 IS H, CL, METHYL OR METHOXY, R2 IS H, ALKYL OF 1 TO 4 CARBON ATOMS, BENZYL, PHENYL OR SUBSTITUTED PHENYL IN WHICH THE SUBSTITUENT IS SELECTED FROM THE GROUP CONSISTING OF CL, METHYL METHOXY AND TRIFLUOROMETHYL, A1 IS -CH2-, -CH2CH2-, -CO- OR -CH2CO- THE CARBONYL PORTION OF WHICH IS BOUND TO THE N ATOM OF THE PIPERIDINE RING OR -CH(OH)-CH2- THE METHYLENE (-CH2-) PORTION, OF WHICH IS BOUND TO THE N ATOM OF THE PIPERIDINE RING, A2 IS -CH2-, OR =CHCH3, AND Z IS -S-, -SO- OR -SO2-, ARE VASODILATORS OF LOW TOXICITY IN MAMMALS.

Claims