TRI-N-PHENYLGLYCYL DERIVATIVES OF INSULIN

• US 3,591,574 A
• Filed: 05/29/1968
• Issued: 07/06/1971
• Est. Priority Date: 05/29/1968
• Status: Expired due to Term

• Current Assignee: Harvey E. Alburn, Norman H. Grant, Richard L. Fenichel
• Original Assignee: Harvey E. Alburn, Norman H. Grant, Richard L. Fenichel
• Inventors: Fenichel, Richard L., Grant, Norman H., Alburn, Harvey E.
• Application Number:
  US04/732,812
• Time in Patent Office: 1,133 Days
• US Class Current: 530/303
• CPC Class Codes: C07K 1/063 for alpha-amino functions
• CPC Class Codes: C07K 14/625 Extraction from natural sources

Abstract

ACYL-SUBSTITUTED-INSULINS, PARTICULARLY PHENYL- AND SUBSTITUTED-PEHNYLGLYCYL-INSULINS, ESPECIALLY N-PHENYLGLYCYLINSULIN, N-P-METHYLPHENYLGLYCYL-INSULIN AND N-P-CHLOROPHENYLGLYCYL-INSULIN (1), ARE PREPARED BY TREATING INSULIN WITH AN ACYLATING AGENT, ESPECIALLY THE CORRESPONDING NCHLOROFORMYL-N-PHENYL OR SUBSTITUTED-PHENYLGLYCIN (II). THE NEW COMPOUNDS (I) HAVE HYPOGLYCEMIC ACTIVITY AND ARE USEFUL TO TREAT DIABETES, ESPECIALLY IN SUBJECTS WHO ARE INSULIN FAST.

Claims