BANDAGE FOR ADMINISTERING DRUGS
First Claim
1. A medical bandage for use in the continuous administration to circulation of controlled quantities of systemically active drugs over a prolonged period of time by absorption through the external body skin or mucosa, said bandage comprising (1) a backing member bearing (2) a pressure-sensitive adhesive on one surface thereof, said pressure-sensitive adhesive having distributed therethrough (3) a plurality of discrete microcapsules, each of which microcapsules comprising a systemically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drUg from the said microcapsules to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time.
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Accused Products
Abstract
Bandage for use in the continuous administration of drugs by absorption comprising a backing member bearing a pressuresensitive adhesive layer on one surface thereof. Distributed throughout the pressure-sensitive adhesive are microcapsules comprised of a systemically active drug encapsulated with a material permeable to passage of the drug. The drug is in a form acceptable for absorption through the skin or the mucosa of the mouth.
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Citations
13 Claims
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1. A medical bandage for use in the continuous administration to circulation of controlled quantities of systemically active drugs over a prolonged period of time by absorption through the external body skin or mucosa, said bandage comprising (1) a backing member bearing (2) a pressure-sensitive adhesive on one surface thereof, said pressure-sensitive adhesive having distributed therethrough (3) a plurality of discrete microcapsules, each of which microcapsules comprising a systemically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drUg from the said microcapsules to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time.
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2. The bandage as defined by claim 1, wherein each of said microcapsules (3) is comprised of systemically active drug formulation microencapsulated with the said drug release rate controlling wall material.
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3. The bandage as defined by claim 1, wherein each of said microcapsules (3) is comprised of a matrix of the drug release rate controlling wall material, said matrix having the systemically active drug formulation distributed therethrough.
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4. The bandage as defined by claim 1, wherein the systemically active drug formulation is soluble in the drug release rate controlling material.
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5. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is permeable to passage of the systemically active drug formulation.
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6. The bandage as defined by claim 1, wherein the drug formulation comprises a pharmacologically acceptable solvent.
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7. The bandage as defined by claim 1, wherein said drug release rate controlling material is silicone rubber.
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8. The bandage as defined by claim 1, wherein said drug release rate controlling material is a hydrophilic polymer of an ester of an olefinic acid.
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9. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is adapted to provide a liquidtight adhesive seal between the skin or mucosa and the bandage.
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10. The bandage as defined by claim 1, wherein the surface of a pressure-sensitive adhesive (3) is covered with a protective release coating (4).
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11. The bandage as defined by claim 1, wherein the outer surface of the backing member (1) is coated with a low adhesion backsize (5).
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12. The bandage as defined by claim 1, wherein said microcapsules have an average particle size of from 1 to 1,000 microns.
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13. The bandage as defined by claim 1, wherein the adhesive face of the bandage has an area of 0.5 to 400 square centimeters.
Specification