DEVICES FOR TESTING BIOLOGICAL LIQUIDS

• US 3,607,093 A
• Filed: 02/15/1968
• Issued: 09/21/1971
• Est. Priority Date: 02/15/1968
• Status: Expired due to Term

• Current Assignee: Ellery W. Stone
• Original Assignee: Ellery W. Stone
• Inventors: Stone, Ellery W.
• Primary Examiner(s): Scovronek, Joseph
• Application Number:
  US04/705,603
• Time in Patent Office: 1,314 Days
• Field of Search: 23/253TP,23B 195/103.5,127 210/23,321,501,502,506
• US Class Current: 422/422
• CPC Class Codes: B01D 61/38 Liquid-membrane separation
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: G01N 33/523 the element being adapted for a specific analyte
• CPC Class Codes: Y10T 436/144444 Glucose
• CPC Class Codes: Y10T 436/146666 Bile pigment
• CPC Class Codes: Y10T 436/255 including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

Testing devices for biological liquids comprise liquid permeable membranes of uniform chemical composition having a solid diagnostic reagent composition incorporated in at least a portion thereof and having at least one surface portion impenetrable by particles of the order of size of red blood corpuscles. The membranes may be of substantially uniform porosity throughout or they may have a thin skin portion of low effective porosity and a thicker body portion having pores of substantially large effective diameters.

Claims

2. A testing device as defined in claim 1 wherein said one surface of the membrane has substantially no surface roughness larger than the size of red blood corpuscles.

3. A testing device as defined in claim 1 wherein said one surface of the membrane is impenetrable by particles of the order of size of hemoglobin molecules.

4. A testing device as defined in claim 1 wherein said one surface of the membrane is penetrable by particles not exceeding about 20,000 in molecular weight and impenetrable by particles exceeding about 50,000 in molecular weight.

5. A testing device as defined in claim 1 wherein a portion of the membrane other than said one surface is penetrable by particles substantially larger than particles capable of penetrating said one surface.

6. A testing device as defined in claim 1 wherein at least the portion of the membrane other than said one surface includes therein a solid diagnostic reagent composition.

7. A testing device as defined in claim 1 wherein the diagnostic reagent composition is responsive by a color change to the presence of glucose in biological liquids in contact with the membrane.