ANTIDEPRESSANT METHOD AND COMPOSITION FOR SAME COMPRISING A TRICYCLIC ANTIDEPRESSANT AND A THYROID HORMONE

• US 3,621,096 A
• Filed: 04/03/1969
• Issued: 11/16/1971
• Est. Priority Date: 04/03/1969
• Status: Expired due to Term

• Current Assignee: Arthur J. Prange Jr, Ian C. Wilson, Morris A. Lipton
• Original Assignee: Arthur J. Prange Jr, Ian C. Wilson, Morris A. Lipton
• Inventors: Arthur, J. Prange Jr., Ian, C. Wilson, Morris, A. Lipton
• Primary Examiner(s): Stanley J. Friedman
• Application Number:
  US04/813,294
• Time in Patent Office: 957 Days
• Field of Search: 424/244,319
• US Class Current: 514/217
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61K 38/22 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin A61K38/33, e.g. corticotropin A61K38/35
• CPC Class Codes: A61K 9/2018 Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/2059 Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
• CPC Class Codes: A61K 9/4858 Organic compounds

Abstract

The antidepressant action of tricyclic antidepressants is enhanced by concurrent administration of thyroid hormone. A composition for treating depression comprises a tricyclic antidepressant and a thyroid hormone in pharmaceutically effective amounts admixed with a pharmaceutical carrier.

Claims

2. A method as in claim 1 wherein the tricyclic antidepressant is imipramine.

3. A method as in claim 1 wherein the thyroid hormone is L-triiodothyronine.

4. A method as in claim 2 wherein the thyroid hormone is L-triiodothyronine.

5. A peroral composition for the treatment of mental depression which comprises an antidepressant effective amount of a mixture of a tricyclic antidepressant selected from the group consisting of imipramine and desmethylimipramine, and a thyroid hormone selected from the group consisting of L-triiodothyronine and L-tetraiodothyronine in admixture with a perorally acceptable pharmaceutical carrier, the ratio of active constituents being about 75-250 mg. tricyclic antidepressant to about 15-50 Mu g. hormone.

6. A composition as in claim 5 in peroral dosage unit form wherein the tricyclic antidepressant is present in an amount sufficient to give a daily dosage of from about 75 to 250 mg. when administered according to a desired daily dosage regimen and the thyroid hormone is present in an amount sufficient to give a daily dosage of from 15 to about 50 Mu g. when administered according to a desired daily dosage regimen.

7. A composition in dosage unit form for use in treating mental depression which comprises from about 20 to about 50 mg. of imipramine, about 5 to about 10 Mu g. of L-triiodothyronine and a solid perorally acceptable pharmaceutical carrier.