CERTAIN PYRIDYL-1 2 4-OXADIAZOLE DERIVATIVES

• US 3,647,809 A
• Filed: 04/08/1969
• Issued: 03/07/1972
• Est. Priority Date: 04/26/1968
• Status: Expired due to Term

• Current Assignee: Bako Erzsebet, Gonczi Csaba, Korbonits Dezso, Leszkovszky Gyorgy, Reiter Kalman Harsanyi Jozsef, Takacs Kalman, Tardos Laszlo, Vertesy Csaba
• Original Assignee: Bako Erzsebet, Gonczi Csaba, Korbonits Dezso, Leszkovszky Gyorgy, Reiter Kalman Harsanyi Jozsef, Takacs Kalman, Tardos Laszlo, Vertesy Csaba
• Inventors: REITER KALMAN HARSANYI JOZSEF, KORBONITS DEZSO, GONCZI CSABA, TAKACS KALMAN, BAKO ERZSEBET, LESZKOVSZKY GYORGY, TARDOS LASZLO, VERTESY CSABA
• Application Number:
  US04/815,520
• Time in Patent Office: 1,064 Days
• US Class Current: 546/256
• CPC Class Codes: C07D 271/06 1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond

Abstract

A 1,2,4-OXADIAZOLE FOR USE AS A PHARMACEUTICALLY ACTIVE AGENT WITH SPASMOLYTIC, ANTIPYRETIC, ANALGESIC, HYPNOTIC OR ANTIRHEUMATIC PROPERTIES. THE COMPOUND IS OF THE FORMULA

3-R1,5-R2-1,2,4-OXADIAZOLE

WHEREIN R1 CONSISTS OF 2-PYRIDYL, 3-PYRIDYL OR 4-PYRIDYL UNSUBSTITUTED OR SUBSTITUTED WITH AN ALKYL GROUP HAVING 1 TO 6 CARBON ATOMS, AND WHEREIN R2 IS PHENYL, HALOPHENYL AMINOPHENYL, HYDROXYPHENYL OR CHLOROPHENOXYMETHYL. THE APPLICATION ALSO DISCLOSES THE HYDROCHLORIDE, HYDROBROMIDE, SULFATE, PHOSPHATE, MALEATE, LACTATE, ACETATE OR TARTARATE ACID-ADDITION SALT OF THE 1,2,4-OXADIAZOLE AND ITS ALKYHALOGENIDE-QUATERNIZED OR ALKYLSULFATEQUATERENIZED PHARMACEUTICALLY ACCEPTABLE SALT WHEREIN THE ALKYL GROUP OF THE QUATERNIZING COMPOUND CONTAINS 1 TO 6 CARBON ATOMS.

Claims