PROTRACTED ACTIVITY ORAL HYDROGEL BEAD

• US 3,689,634 A
• Filed: 09/23/1970
• Issued: 09/05/1972
• Est. Priority Date: 01/06/1966
• Status: Expired due to Term

• Current Assignee: Jiri Vacik, Karel Kliment, Miroslav Stol, Otto Wichterle, Vladimir Majkus, Vladimir Stoy, Zdenek Ott
• Original Assignee: Jiri Vacik, Karel Kliment, Miroslav Stol, Otto Wichterle, Vladimir Majkus, Vladimir Stoy, Zdenek Ott
• Inventors: Vacik, Jiri, Stol, Miroslav, Stoy, Vladimir, Wichterle, Otto, Ott, Zdenek, Majkus, Vladimir, Kliment, Karel
• Primary Examiner(s): Shep K. Rose
• Application Number:
  US05/074,905
• Time in Patent Office: 713 Days
• Field of Search: 424/19-22,81
• US Class Current: 424/475
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: C08F 36/20 unconjugated

Abstract

Drugs are released gradually to a living organism after oral ingestion, through a layer of non-ionogenic, neutral hydrogel of a polymer of ethylene glycol methacrylate or similar monomer cross-linked sufficiently to make the polymer insoluble in all gastro intestinal liquids.

Claims

2. The carriers according to claim 1 wherein said particles comprise a core consisting of said beads as a macroporous hydrogel containing the saturated biologically active oral therapeutic substance, and an outer inert acid resistant coating layer, said carriers intended for treating diseases of the gastro-intestinal tract.

3. The carrier according to claim 1 wherein said thickness and diffusion rates are predetermined and predefined to provide a controlled delivery for tetracyline hydrochloride from each particle.

4. The carrier according to claim 3 wherein said tetracyline hydrochloride as the biological substance comprises about 1 percent of said mixture.

5. The carrier according to claim 1 wherein said mixture comprises fractions of one part 0.1 - 0.5 parts of 0.5 - 1 mm and three parts of 1 - 2 mm beads prepared in bead form 0.1 -2.0 mm in size.