ANTIDEPRESSANT METHOD AND COMPOSITION

• US 3,689,669 A
• Filed: 10/09/1970
• Issued: 09/05/1972
• Est. Priority Date: 10/09/1970
• Status: Expired due to Term

• Current Assignee: Arthur J. Prange Jr, Ian C. Wilson, Morris A. Lipton
• Original Assignee: Arthur J. Prange Jr, Ian C. Wilson, Morris A. Lipton
• Inventors: Arthur, J. Prange Jr., Morris, A. Lipton, Ian, C. Wilson
• Primary Examiner(s): Stanley J. Friedman
• Application Number:
  US05/079,704
• Time in Patent Office: 697 Days
• Field of Search: 424/319,330
• US Class Current: 514/567
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/18 Iodine; Compounds thereof

Abstract

The antidepressant action of tricyclic antidepressants is enhanced by concurrent administration of thyroid hormone. A composition for treating depression comprises a tricyclic antidepressant and a thyroid hormone in pharmaceutically effective amounts admixed with a pharmaceutical carrier.

Claims

2. A method as in claim 1 wherein the thyroid hormone is L-triiodothyronine.

3. A method as in claim 1 wherein the tricyclic antidepressant is amitriptyline.

4. A method as in claim 1 wherein the tricyclic antidepressant is amitriptyline and the thyroid hormone is L-tetraiodothyronine.

5. A method as in claim 4 wherein the thyroid hormone is L-triiodothyronine.

6. A peroral composition for the treatment of mental depression which comprises an antidepressant effective amount of a mixture of a tricyclic antidepressant selected from the group consisting of nortriptyline, amitriptyline and protriptyline and a thyroid hormone selected from the group consisting of L-triiodothyronine and L-tetraiodothyronine in admixture with a perorally acceptable pharmaceutical carrier, the ratio of active constituents being about 75 - 250 mg. tricyclic antidepressant to about 15 - 50 mg. hormone.

7. A composition as in claim 6 in peroral dosage unit form wherein the tricyclic antidepressant is present in an amount sufficient to give a daily dosage of from about 75 to 250 mg. when administered according to a desired daily dosage regimen and the thyroid hormone is present in an amount sufficient to give a daily dosage of from 15 to 50 mg. when administered according to a desired daily dosage regimen.

8. A composition in dosagE unit form for use in treating mental depression which comprises from about 20 to about 50 mg of amitriptyline, about 5 to about 10 Mu g of L-tetraiodothyronine and a solid perorally acceptable pharmaceutical carrier.