ENHANCING TISSUE PENETRATION OF PHYSIOLOGICALLY ACTIVE STEROIDAL AGENTS WITH DMSO

• US 3,711,606 A
• Filed: 09/02/1970
• Issued: 01/16/1973
• Est. Priority Date: 09/02/1970
• Status: Expired due to Term

• Current Assignee: Gay Lord Container Corporation (International Paper Company)
• Original Assignee: Robert John Herschler
• Inventors: Herschler, Robert John
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/069,155
• Time in Patent Office: 867 Days
• Field of Search: 424/243,337
• US Class Current: 514/174
• CPC Class Codes: A61K 47/20 containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00

Abstract

A method of enhancing tissue penetration of physiologically active steroidal agents by conjointly applying them to the tissue with dimethyl sulfoxide. Penetration of the skin and the mucous membranes of the body cavities by these agents may be enhanced by cojoint application of such agents and dimethyl sulfoxide directly to such membranes. Preferably, for penetration of these agents through the skin compositions of DMSO at concentrations of 50 percent and above are employed and for penetration through mucous membranes, compositions including DMSO at concentrations of 10 percent and above are employed. Steroidal Agents may be advantageously administered by injection with DMSO in concentrations preferably up to 20 percent by weight to enhance penetration of internal tissue membranes barriers to achieve better distribution of these agents.

Claims

2. A method as in claim 1 and wherein the said agent is applied to the intact skin in a composition which includes said DMSO and wherein the DMSO in said composition is at least about 50 percent by weight of the composition.

3. A method as in claim 1 and wherein said agent is applied to induce at least a physiological effect locally to the site of application.

4. A method as in claim 1 and wherein said glucocorticoid is a 3-keto, Delta 4, 11-oxygen function, 20-keto steroid of the pregnane series.

5. A method as in claim 4 and wherein said glucocorticoid is a 11-hydroxy steroid.

6. A method as in claim 1 and wherein said agent is applied to said membrane in a composition which includes said DMSO.

7. A method as in claim 6 and wherein said composition contains a pharmaceutically acceptable thickening agent in an amount sufficient to materially increase the viscosity thereof, whereby to facilitate topical application.

8. A method as in claim 7 wherein said composition is in the form of an ointment.

9. A method as in claim 7 and wherein said composition is in the form of a lotion.