3-OXO-1-OXA-4,8-DIAZASPIRO(4.5)DECANES

• US 3,723,442 A
• Filed: 12/31/1970
• Issued: 03/27/1973
• Est. Priority Date: 12/31/1970
• Status: Expired due to Term

• Current Assignee: Hideki Ao, Katsuo Arimura, Michio Nakanishi
• Original Assignee: Hideki Ao, Katsuo Arimura, Michio Nakanishi
• Inventors: Nakanishi, Michio, Ao, Hideki, Arimura, Katsuo
• Primary Examiner(s): Jiles, Henry R.
• Assistant Examiner(s): Todd, G. Thomas
• Application Number:
  US05/103,322
• Time in Patent Office: 817 Days
• Field of Search: 260/244R,293.66
• US Class Current: 546/19
• CPC Class Codes: C07D 498/10 Spiro-condensed systems

Abstract

3-OXO-1-OXA-4,8-DIAZASPIRO(4.5)DECANES HAVING THE GENERAL FORMULA

WHEREIN R, R1, R2, R3 and n are defined hereinafter, their pharmaceutically acceptable acid addition salts thereof and methods for the preparation of said compounds are disclosed. The compounds are used as agents having strong reserpine antagonistic activity and agents for lowering the blood sugar level.

Claims

2. The compound of claim 1, wherein said compound is 2-methyl-3-oxo-1-oxa-4,8-diazaspiro(4.5)decane.

3. The compound of claim 1, wherein said compound is 3-oxo-2-phenyl-1-oxa-4,8-diazaspiro(4.5)decane.

4. The compound of claim 1, wherein said compound is 8-ethoxy-carbonyl-2-methyl-3-oxo-1-oxa-4,8-diazaspiro(4.5)decane.

5. The compound of claim 1, wherein said compound is 2-methyl-3-oxo-8-phenethyl-1-oxa-4,8-diazaspiro(4.5)decane.

6. The compound of claim 1, wherein said compound is 8-benzoyl-2-methyl-3-oxo-1-oxa-4,8-diazaspiro(4.5)decane.

7. The compound of claim 1, wherein said compound is 8-(2-cyanoethyl)-2-methyl-3-oxo-1-oxa-4,8-diazaspiro(4.5)decane.