GERMICIDAL IODINE COMPOSITIONS FOR APPLICATION TO SKIN TISSUE INCLUDING TEATS OF MILK ANIMALS
First Claim
2. A germicidal composition as defined in claim 1 wherein said polyhydric alcohols are members selected from the group consisting of glycerin, propylene glycol, mannitol, sorbitol, and mixtures thereof.
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Accused Products
Abstract
An improved germicidal-iodine composition for application to skin tissue and particularly to teats of milk animals in the control of mastitis, wherein an aqueous nonionic carrier-iodine composition providing available iodine concentration in the range of about 0.25 to 2 percent, and containing nonionic carriers of the types which have been cleared for use in contact with food equipment in an amount providing a ratio of carrier to available iodine within the range of 5:1 to 20:1, is supplemented by an emollient in the form of a water-soluble polyhydric alcohol or ethoxylated lanolin, and the emollient is protected against reaction with the iodine by providing a suitably high distribution coefficient for the iodine and maintaining a pH in the composition in the range of about pH 3 - 6.5, and preferably buffered at about pH 3.5 - 4.5. Buffering can be effected by various food acids and salts of food acids.
58 Citations
12 Claims
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2. A germicidal composition as defined in claim 1 wherein said polyhydric alcohols are members selected from the group consisting of glycerin, propylene glycol, mannitol, sorbitol, and mixtures thereof.
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3. A germicidal composition as defined in claim 1 wherein said available iodine is present as elemental iodine in association with a water soluble inorganic iodide in an amount to provide at least 0.35 parts by weight of iodide (I ) per part by weight of iodine.
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4. A germicidal composition as defined in claim 1 wherein said sustained pH is provided by buffering agents comprising any of the recognized food acids and mixtures thereof.
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5. A germicidal composition as defined in claim 4 wherein the quantity of buffering agent is such as to provide a 0.02 - 0.25 molar buffer content, and the pH is buffered within the range of pH 3.5 to 4.5.
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6. A germicidal compositiOn as defined in claim 1 wherein the emollient is a polyhydric alcohol and is present in the amount of about 10 percent by weight.
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7. A germicidal composition as defined in claim 6 wherein the emollient is glycerin.
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8. A germicidal composition as defined in claim 6 wherein the emollient is sorbitol.
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9. A germicidal composition as defined in claim 6 wherein the emollient is propylene glycol.
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10. A germicidal composition as defined in claim 6 wherein the emollient is mannitol.
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11. A germicidal composition as defined in claim 1 wherein the emollient is ethoxylated lanolin and is present in the amount of about 2 to 3 percent by weight.
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12. A germicidal composition for application to skin tissue and particularly to teats of milk animals in the control of mastitis, said composition consisting essentially of an aqueous solution containing available iodine in the amount of about 0.25 to 2 percent by weight, said iodine being complexed with a nonionic iodine carrier selected from the group consisting of a. alkyl phenol ethylene oxide condensates wherein the alkyl group contains 8-12 carbon atoms and the condensate contains about 7-18 mols of ethylene oxide per mol of alkyl phenol, b. nonionics embraced by the formula:
- HO(C2H4O)x(C3H6O)y(C2H4O)x -H wherein y equals at least 15 and (C2H4O)x x equals 20 to 90 percent of the total weight of said compound, c. nonionics which are ethoxylated partial esters of fatty acids with sugar alcohols containing an average of 1 - 3 ester groups and up to 50 mols of ethylene oxide per molecule, d. butoxy derivatives of polyethylene oxide, ethylene oxide, block polymers having molecular weights within the range of about 2,000 - 5,000, e. poly(N-vinyl-2-pyrrolidone), and f. mixtures thereof, said iodine carrier being present in an amount to provide a ratio of carrier to available iodine within the range of 5;
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1, an emollient selected from the group consisting of polyhydric alcohols, water soluble ethoxylated lanolin, and mixtures thereof, said polyhydric alcohols being present in an amount of about 5 to 25 percent of said composition and said water soluble ethoxylated lanolin being present in an amount of about 1 to 10 percent of said composition, said solution having a sustained pH in the range of about pH 3 - 6.5 and containing sufficient inorganic iodide to provide a distribution coefficient sufficiently high to satisfy the formula;
D.C. number/Percent available iodine at least 75, said pH range and said distribution coefficient serving to prevent said emollient from reacting with said available iodine.
- HO(C2H4O)x(C3H6O)y(C2H4O)x -H wherein y equals at least 15 and (C2H4O)x x equals 20 to 90 percent of the total weight of said compound, c. nonionics which are ethoxylated partial esters of fatty acids with sugar alcohols containing an average of 1 - 3 ester groups and up to 50 mols of ethylene oxide per molecule, d. butoxy derivatives of polyethylene oxide, ethylene oxide, block polymers having molecular weights within the range of about 2,000 - 5,000, e. poly(N-vinyl-2-pyrrolidone), and f. mixtures thereof, said iodine carrier being present in an amount to provide a ratio of carrier to available iodine within the range of 5;
Specification