IONICALLY BONDED BLOCK ELASTOMERIC COPOLYMERS OF A POLYQUATERNARY POLYURETHANE AND HEPARIN

• US 3,755,218 A
• Filed: 08/14/1970
• Issued: 08/28/1973
• Est. Priority Date: 08/14/1970
• Status: Expired due to Term

• Current Assignee: Alan Rembaum, Shiao-Ping Siao Yen
• Original Assignee: Alan Rembaum, Shiao-Ping Siao Yen
• Inventors: Yen, Shiao-Ping Siao, Rembaum, Alan
• Primary Examiner(s): Short, William H.
• Assistant Examiner(s): Woodberry, Edward
• Application Number:
  US05/063,722
• Time in Patent Office: 1,110 Days
• Field of Search: 260/77.5Q,77.5AS,9,858,859 424/78,83,183 117/138.8E,62.1
• US Class Current: 428/35.5
• CPC Class Codes: A61L 33/0023 using a quaternized group or a protonated amine group of the substrate
• CPC Class Codes: C08G 18/0814 containing ammonium groups or groups forming them
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/3275 containing two hydroxy groups
• CPC Class Codes: C08G 18/329 containing aromatic groups
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 75/00 Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: Y10S 128/22 Blood coagulation
• CPC Class Codes: Y10T 428/1345 Single layer [continuous layer]
• CPC Class Codes: Y10T 428/31554 Next to second layer of polyamidoester
• CPC Class Codes: Y10T 428/31565 Next to polyester [polyethylene terephthalate, etc.]
• CPC Class Codes: Y10T 428/31587 Hydrocarbon polymer [polyethylene, polybutadiene, etc.]
• CPC Class Codes: Y10T 428/31598 Next to silicon-containing [silicone, cement, etc.] layer
• CPC Class Codes: Y10T 428/31601 Quartz or glass

Abstract

A neutral elastomer is prepared by the urethane linking reaction of diisocyanates with tertiary amino diols. The neutral elastomer is quaternized and is then reacted with an anionic polymer such as heparin to form ionically bonded block elastomeric copolymers. The heparin copolymer has non-thrombogenic characteristics. It can be dissolved in solvents and utilized to form a non-clotting coat on the blood lines in kidney machines.

Claims

2. An elastomer according to claim 1 in which the heparin content is between 10 and 15%, and the elastomer is dissolved in a solvent selected from the group consisting of polar solvents and mixtures thereof with an alkyl amine.

3. An elastomer according to claim 2 in which said solvent is selected from dioxane, acetone, tetrahydrofuran, dimethylformamide and mixtures thereof with 0.01 to 5% of a primary or secondary alkylamine.

4. An elastomer according to claim 3 in which the solvent is a mixture of dimethylformamide and diaminoheptane.

5. A method of rendering a surface nonthrombogenic comprising covering said surface with a film comprising the elastomer of claim 1.

6. A method according to claim 5 in which said surface is prepared by molding a shaped article from said elastomer.

7. A method according to claim 5 in which said surface is formed by casting a film of said elastomer.

8. A method according to claim 5 in which said surface is formed by coating a substrate with a solution according to claim 2 and evaporating the solvent therefrom.

9. An article of manufacture comprising a film of the ionic block elastomer as defined in claim 1.

10. An article according to claim 9 in which the film is supported on a substrate.

11. An article according to claim 10 in which the substrate is selected from the group consisting of polyvinyl, polytetrafluoroethylene, polyester, silicone resins, glass, polystyrene and polyurethane.

12. An article according to claim 9 in which said film is in tubular shape.