IONICALLY BONDED BLOCK ELASTOMERIC COPOLYMERS OF A POLYQUATERNARY POLYURETHANE AND HEPARIN
First Claim
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2. An elastomer according to claim 1 in which the heparin content is between 10 and 15%, and the elastomer is dissolved in a solvent selected from the group consisting of polar solvents and mixtures thereof with an alkyl amine.
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Abstract
A neutral elastomer is prepared by the urethane linking reaction of diisocyanates with tertiary amino diols. The neutral elastomer is quaternized and is then reacted with an anionic polymer such as heparin to form ionically bonded block elastomeric copolymers. The heparin copolymer has non-thrombogenic characteristics. It can be dissolved in solvents and utilized to form a non-clotting coat on the blood lines in kidney machines.
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Citations
12 Claims
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2. An elastomer according to claim 1 in which the heparin content is between 10 and 15%, and the elastomer is dissolved in a solvent selected from the group consisting of polar solvents and mixtures thereof with an alkyl amine.
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3. An elastomer according to claim 2 in which said solvent is selected from dioxane, acetone, tetrahydrofuran, dimethylformamide and mixtures thereof with 0.01 to 5% of a primary or secondary alkylamine.
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4. An elastomer according to claim 3 in which the solvent is a mixture of dimethylformamide and diaminoheptane.
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5. A method of rendering a surface nonthrombogenic comprising covering said surface with a film comprising the elastomer of claim 1.
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6. A method according to claim 5 in which said surface is prepared by molding a shaped article from said elastomer.
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7. A method according to claim 5 in which said surface is formed by casting a film of said elastomer.
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8. A method according to claim 5 in which said surface is formed by coating a substrate with a solution according to claim 2 and evaporating the solvent therefrom.
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9. An article of manufacture comprising a film of the ionic block elastomer as defined in claim 1.
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10. An article according to claim 9 in which the film is supported on a substrate.
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11. An article according to claim 10 in which the substrate is selected from the group consisting of polyvinyl, polytetrafluoroethylene, polyester, silicone resins, glass, polystyrene and polyurethane.
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12. An article according to claim 9 in which said film is in tubular shape.
Specification