GLUCOSE DETERMINATION APPARATUS

• US 3,770,607 A
• Filed: 10/15/1971
• Issued: 11/06/1973
• Est. Priority Date: 04/07/1970
• Status: Expired due to Term

• Current Assignee: David L. Williams
• Original Assignee: David L. Williams
• Inventors: Williams, David L.
• Primary Examiner(s): Tung, T.
• Application Number:
  US05/189,589
• Time in Patent Office: 753 Days
• US Class Current: 204/403.09
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

An electrochemical apparatus especially applicable for clinical use in determining glucose concentrations in solutions thereof comprising (1) a sample reservoir, (2) a glucose oxidase cell consisting essentially of a well closed at the bottom by a dialysis membrane and containing an anode, glucose oxidase and a buffer solution, (3) a reference cell consisting essentially of a well closed at the bottom by a dialysis membrane and containing an anode and buffer solution, (4) a cathode, (5) means for positioning the cells and the cathode in the sample reservoir (6) means for applying a voltage between the cathode and the anodes, and (7) means for measuring electrical current produced in the cells. The process for using the apparatus comprises adding a buffered glucose solution to the sample reservoir, immersing the cathode and cells into the solution, adding a quinone either to the cells or to the glucose solution, applying a voltage between the cathode and the anodes and measuring the current produced in the cells.

Claims

2. A device as in claim 1 wherein the cathode and anodic cells are removably mounted into a header which is removably mounted in the reservoir to maintain the cathode and cells in position therein.

3. A device as in claim 1 wherein the current measuring means include means for automatically recording the differential in current produced in the cells.