NOVEL DRUG DELIVERY DEVICE FOR ADMINISTERING DRUG INTO BLOOD CIRCULATION IN BLOOD VESSEL

• US 3,797,485 A
• Filed: 03/26/1971
• Issued: 03/19/1974
• Est. Priority Date: 03/26/1971
• Status: Expired due to Term

• Current Assignee: John Urquhart
• Original Assignee: John Urquhart
• Inventors: Urquhart, John
• Primary Examiner(s): Truluck, Dalton L.
• Application Number:
  US05/128,303
• Time in Patent Office: 1,089 Days
• Field of Search: 128/1R,213,260,268,334 424/14,16,19
• US Class Current: 604/288.04
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A novel drug delivery device for administering a drug into the blood circulation comprising a means for positioning a drug supply on the adventitial surface of an intact blood vessel for diffusing the drug into the blood in the blood vessel.

Claims

1. A drug delivery device for directly diffusively administering a drug into the blood through the walls of an intact blood vessel confining the same, comprising a hollow, elongate, bulbous tubule member tapered at its ends and having interior and exterior wall surfaces adapted to sealingly circumferentially engage the adventitial surface of a blood vessel longitudinally extending therethrough at both the proximal and distal ends thereof to form a pair of well-defined sealed interfaces therewith, and defining reservoir means for confining a drug supply in an annular interspace between the interior wall surface of said tubule member and the exterior wall of such blood vessel, said tubule member being provided with both inlet means and outlet means for filling and emptying the interspace, and the said tubule member being essentially impermeable to the drug and body fluid, whereby, in vivo, and confining a drug supply, the drug diffuses therefrom and through the walls of the intact blood vessel directly into the blood circulation in the intact blood vessel.

2. A drug delivery device for directly diffusively administering a drug into the blood through the walls of an intact blood vessel confining the same, comprising an elongate first tubule member having interior and exterior wall surfaces adapted to circumferentially engage the adventitial surface of a blood vessel longitudinally extending therethrough at both the proximal and distal ends thereof;

a second tubule member having interior and exterior wall surfaCes concentrically disposed within said first tubule member, comprising drug release rate controlling membrane, and sealingly circumferentially affixed to said first tubule member at the proximal and distal ends thereof and adapted to longitudinally extend therethrough closely adjacent the adventitial surface of the blood vessel;

the interior walls of said first tubule member defining a sealed, annular interspace for confining a drug supply, said first tubule member being provided with both inlet means and outlet means for filling and emptying the interspace; and

the said first tubule member being essentially impermeable to the drug and body fluid, whereby, in vivo, and confining a drug supply, the drug diffuses therefrom through the membrane and to and through the walls of the intact blood vessel directly into the blood circulation in the intact blood vessel.

3. A drug delivery device for directly diffusively administering a drug into the blood through the walls of an intact blood vessel confining the same, comprising a hollow, elongate tubule member having interior and exterior wall surfaces and circumferentially inwardly descending skirt members integral therewith and annularly depending therefrom at both the proximal and distal ends thereof, said skirt members adapted to sealingly circumferentially engage the adventitial surface of a blood vessel longitudinally extending through the tubule member to form a pair of well-defined sealed circumferential interfaces therewith, and said tubule member and skirt members depending therefrom defining reservoir means for confining a drug supply in an annular interspace between the interior wall surface of said tubule member and the exterior wall of such blood vessel, said tubule member being provided with both inlet means and outlet means for filling and emptying the interspace, and the said tubule member and skirt members being essentially impermeable to the drug and body fluid, whereby, in vivo, and confining a drug supply, the drug diffuses therefrom and through the walls of the intact blood vessel directly into the blood circulation in the intact blood vessel.

4. A drug delivery device for directly diffusively administering a drug into the blood through the walls of an intact blood vessel confining the same, comprising a hollow, elongate first tubule member having interior and exterior wall surfaces and circumferentially inwardly depending skirt members integral therewith and annularly depending therefrom at both the proximal and distal ends thereof, said skirt members adapted to sealingly circumferentially engage the adventitial surface of a blood vessel longitudinally extending through the tubule member to form a pair of well-defined sealed circumferential interfaces therewith;

a second tubule member having interior and exterior wall surfaces concentrically disposed within said first tubule member, comprising drug release rate controlling membrane, and sealingly circumferentially affixed to the skirt members annularly depending from the said first tubule member and adapted to longitudinally extend therethrough closely adjacent the adventitial surface of the blood vessel;

the interior walls of said first tubule member and of the skirt members depending therefrom and the exterior walls of said second tubule member defining a sealed interspace for confining a drug supply, said first tubule member being provided with both inlet means and outlet means for filling and emptying the interspace; and

the said first tubule member and the skirt members depending therefrom being essentially impermeable to the drug and body fluid, whereby, in vivo, and confining a drug supply, the drug diffuses therefrom through the membrane and to and through the walls of the intact blood vessel directly into the blood circulation in the intact blood vessel.

5. A drug delivery device for directly diffusively administering a drug into the blood through the walls of an intact blood vessel confining the same, comprising a first saddle member having iNterior and exterior wall surfaces adapted to sealingly engage the adventitial surface of a blood vessel longitudinally extending thereunder completely about the periphery thereof to form a well-defined, sealed, continuous peripheral interface therewith;

a second saddle member having interior and exterior wall surfaces disposed beneath said first saddle member, comprising drug release rate controlling membrane, and sealingly continuously peripherally affixed to said first saddle member and adapted to extend thereunder closely adjacent the adventitial surface of the blood vessel;

the interior walls of said first saddle member and the exterior walls of said second saddle member defining a sealed interspace for confining a drug supply, said first saddle member being provided with both inlet means and outlet means for filling and emptying the interspace; and

the said first saddle member being essentially impermeable to the drug and body fluid, whereby, in vivo, and confining a drug supply, the drug diffuses therefrom through the membrane and to and through the walls of the intact blood vessel directly into the blood circulation in the intact blood vessel.

6. The drug delivery device as defined by claim 5, wherein the first saddle member is essentially uniformly semi-circular in cross-sectional configuration in the directon along the major axis thereof.

7. The drug delivery device as defined by claim 5, wherein the first saddle member is further of a configuration adapted to helically engage the adventitial surface of the blood vessel.

8. The drug delivery device as defined by claim 1, wherein the inlet means further comprises a bacterial filter.

9. In a process for administering a therapeutically effective amount of an acceptable drug into the blood within an intact blood vessel wherein the process comprises placing a drug delivery device adapted for supplying a drug on the adventitial surface of a blood vessel, the device comprised of a wall formed of a material essentially impermeable to drug within the wall forming a reservoir and adapted to embrace the adventitial surface of the blood vessel, a reservoir for supplying drug and defined by the inner surface of the wall, an inlet port and an outlet port connected to the reservoir for supplying drug to the reservoir, and wherein drug is released from the reservoir when charged with drug and in contact with the adventitial surface for diffusively administering the drug through the blood vessel and into the blood from the device.

10. In a process for administering a drug from a drug delivery device according to claim 9 wherein the drug is diffusively administered into the blood to produce a localized effect.

11. In a process for administering a drug from a drug delivery device according to claim 9 wherein in the drug is diffusively administered into the blood to produce a systemic effect.

12. In a process for administering a drug from a drug delivery device according to claim 9 wherein the device further comprises a drug release rate controlling membrane permeable to the passage of drug for controlling the rate of drug diffusion from the device to the adventitial surface of the blood vessel wall, said membrane positioned and joined to the edges of inner surface of the wall with the drug contained in the reservoir formed by the inner surface of the wall and the membrane.

13. A process for administering a drug from a drug delivery device according to claim 12 wherein the wall and membrane are adapted to form a spiral or helix shaped device.