BANDAGE FOR THE ADMINISTRATION OF DRUG BY CONTROLLED METERING THROUGH MICROPOROUS MATERIALS

• US 3,797,494 A
• Filed: 08/09/1971
• Issued: 03/19/1974
• Est. Priority Date: 04/01/1969
• Status: Expired due to Term

• Current Assignee: Alejandro Zaffaroni
• Original Assignee: Alejandro Zaffaroni
• Inventors: Zaffaroni, Alejandro
• Primary Examiner(s): Truluck, Dalton L.
• Assistant Examiner(s): McGowan, J. C.
• Application Number:
  US05/169,976
• Time in Patent Office: 953 Days
• Field of Search: 128/260,268,156,155,296 424/19,20,28
• US Class Current: 424/434
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61K 9/7076 the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
• CPC Class Codes: A61K 9/7092 Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A bandage for use in the continuous administration of drugs to the skin or mucosa, comprising a backing member defining one exterior surface, a surface of pressure-sensitive adhesive defining a second exterior surface, and disposed therebetween a reservoir containing drug formulation confined therein. The reservoir can comprise a distinct layer of the bandage or a plurality of microcapsules distributed throughout the adhesive surface, and in either case the drug can be confined within an interior chamber of the reservoir or distributed throughout a reservoir matrix. The drug passes through drug release rate controlling microporous material which continuously meters the flow of drug by viscous or diffusive transfer to the skin or mucosa at a controlled and predetermined rate over a period of time.

Claims

2. The bandage as defined by claim 1 wherein the pores of the microporous rate controlling material are filled with a medium to permit controlled diffusion of the drug from the reservoir.

3. A medical bandage for the continuous administration of controlled quantities of drug to the skin or mucosa, comprised of a laminate of:

(1) a backing member;

bearing (2) a discrete middle reservoir containing a drug confined therein, the reservoir being formed of material permeable to passage of the drug; and

(3) a pressure-sensitive adhesive surface adapted for contact with the skin or mucosa and positioned on one surface of the reservoir remote from the backing membeR and wherein one or more drug release rate controlling microporous membranes are interposed between the surface of the reservoir and pressure-sensitive adhesive so as to continuously meter the flow of a therapeutically effective amount of the drug from the reservoir at a controlled and predetermined rate over a period of time.

4. The bandage as defined by claim 3 wherein the reservoir is a container having the drug confined therein.

5. The bandage as defined by claim 4 wherein the reservoir is pressurized to permit controlled microporous flow of the drug from the reservoir.

6. The bandage as defined by claim 3 wherein the reservoir is a solid or microporous matrix having the drug dispersed therein.

7. The bandage as defined by claim 3 wherein the pores of the microporous rate controlling material are filled with a medium to permit controlled diffusion of the drug from the reservoir.