PHARMACEUTICAL COMPOSITIONS CONTAINING THE REACTION PRODUCT OF A TERTIARY PHOSPHINE WITH THYROXINE

• US 3,808,332 A
• Filed: 09/21/1970
• Issued: 04/30/1974
• Est. Priority Date: 01/27/1969
• Status: Expired due to Term

• Current Assignee: Olsen D, Reynolds H
• Original Assignee: Olsen D, Reynolds H
• Inventors: REYNOLDS H, OLSEN D
• Application Number:
  US05/074,125
• Time in Patent Office: 1,317 Days
• US Class Current: 514/75
• CPC Class Codes: C07F 9/54 Quaternary phosphonium compounds
• CPC Class Codes: C07F 9/5442 Aromatic phosphonium compounds (P-C aromatic linkage)

Abstract

A PHARMACEUTICAL COMPOSITION COMPRISING OF A PHARMACEUTICALLY ACCEPTABLE CARRIER AND THE REACTION PRODUCT FORMED BY REACTING LESS THAN A STOICHIOMETRIC AMOUNT OF A TERTIARY PHOSPHINE WITH THYROXINE (FREE ACID) IN A DIPOLAR APROTIC SOLVENT. THE COMPOSITION CONTAINS THYROXINE (FREE ACID) AND 3,5,3'"'"''"'"'-L-TIIODOTHYRONINE IN A PRESELECTED RATIO TO EACH OTHER AND IS USEFUL FOR THE TREATMENT AND CONTROL OF BODY DISORDERS ASSOICATED WITH AN IMPAIRMENT OF THE THYRIOD HORMONE FUNCTION.

Claims